Psychosocial Group Interventions for Depression
- Conditions
- Depression
- Registration Number
- NCT02149381
- Lead Sponsor
- University of Eastern Finland
- Brief Summary
A total of 384 patients suffering from chronic depressive disorder will be randomized to receive treatment as usual, CBASP, or befriending for a period of five months. The primary outcome is change in Montgomery-Åsberg Depression Scale. Secondary outcomes include changes in self-reported psychiatric symptoms, biomarkers determined from venous blood samples, and neurophysiological parameters. The data gathering is performed at pre- and post intervention stages (i.e., at baseline and at five months). A follow-up questionnaire is sent to the participants six months after the intervention.
- Detailed Description
The efficacy of 20-week group-CBASP as compared to TAU is evaluated by RCT in a psychiatric outpatient clinics. The recruition is completed.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 82
- Age 18-65
- Moderate or severe major depression with duration of a minimum of two years OR "double depression" (dysthymia and moderate/severe major depression simultaneously) OR moderate or severe major depression with duration of a minimum of two years, only partially remitted during the time period
- Psychotic disorder
- Bipolar disorder
- Current substance abuse (excluding nicotine)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Depression At baseline and after intervention (at 5 months) Montgomery-Åsberg Depression Rating Scale
- Secondary Outcome Measures
Name Time Method Peripheral blood biomarkers At baseline and after intervention (at 5 mos) Blood samples are collected before and after intervention.
Trial Locations
- Locations (1)
University of Eastern Finland
🇫🇮Kuopio, North Savo, Finland
University of Eastern Finland🇫🇮Kuopio, North Savo, Finland