A comparative analysis on effects of statin pharmacotherapy on pulp chamber calcification - A 3-dimensional radiographic analysis on Indian population

The aim of the study is to evaluate and compare the pulp chamber calcification amongst healthy controls patients with cardiovascular disease not taking statin medication and patients with cardiovascular disease on statin medication using three dimensional volumetric analysis. Patients will be allotted in three groups. Group 1 will constitute healthy individuals without taking any medications Group 2 will constitute cardiovascular patients without any medication Group 3 will constitute cardiovascular patients taking statin medication. CBCT scans will be retrieved from the software database from January 2020 to March 2023 and utilized the patient detailed medical history and dental records to allocate them into the test group and control group. A sample size of 75 with 25 in each of the three group will be taken. The inclusion criteria involve patient with 30 to 45 years of age and presence of healthy either first or second mandibular molars. CBCT scan with the presence of caries large restorations attrition periodontitis previous pulp cap treated teeth endodontically treated teeth patients with history of clenching or grinding will be excluded. Group 1 patients with any systemic diseases and the other two groups with systemic diseases like renal lithiasis gout cholelithiasis and diabetes mellitus will be excluded from the study.

CBCT scans of patients will be taken from PAPAYA 3D. A third party software ONDEMAND 3D will be used for the volumetric analysis. The scan images will be reconstructed and evaluated in different planes including sagittal coronal axial sections. Skilled oral radiologists will use the OnDemand3D software to interpret the images. The data analysis will be performed using the statistical software SPSS version 16.0.