Impact of L-Carnitine infusion on Lipid induced Insulin resistance

Completed

• Conditions: non­insulin dependant diabetes; type 2 diabetes mellitus; 10018424

• Registration Number: NL-OMON43461
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 21

Inclusion Criteria

Caucasian
* Healthy (as determined by responsible physician based on a medical questionnaire)
* Male
* Age: 18-40 years
* Normal BMI: 18-25 kg/m2
* Stable dietary habits
* No use of medication interfering with investigated study parameters (as determined by responsible physician)

Exclusion Criteria

* Female
* Haemoglobin levels < 7.8 mmol/L
* Uncontrolled hypertension
* Use of anticoagulants
* Engagement in exercise > 3 hours a week
* Being vegetarian or vegan (because of altered whole body carnitine status)
* Smoking
* Alcohol and/or drug abuse
* Unstable body weight (weight gain or loss > 5kg in the last 3 months)
* Significant food allergies/intolerances (seriously hampering study meals)
* Participation in another biomedical study within 1 month before the first study visit, which would possibly hamper our study results
* Medication use known to hamper subject*s safety during the study procedures
* Medication use known to interfere with investigated study parameters
* Subjects with contra-indications for MRI
* Subjects who intend to donate blood during the intervention or subjects who have donated blood less than three months before the start of the study
* Subjects who do not want to be informed about unexpected medical findings
* Subjects who do not want that their treating physician is informed

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary study endpoint is whole body insulin sensitivity, measured by the<br /><br>hyperinsulinemic-euglycemic clamp. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary endpoints are maximal acetylcarnitine concentrations after exercise,<br /><br>metabolic compounds in the blood and measurements regarding skeletal muscle<br /><br>metabolism in skeletal muscle tissue obtained by needle biopsies.</p><br>