Confirmation trial for the ameliorating effects of lactobacillus acidophilus strain L-92 on borderline symptoms of perennial allergic rhinitis

Not Applicable

• Conditions: Healthy Adult

• Registration Number: JPRN-UMIN000024464
• Lead Sponsor: Sapporo Yurinokai Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-10-19
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 160

Inclusion Criteria

Not provided

Exclusion Criteria

1.Suffering from a disease requiring treatment urgently, and having a chronic disease except for perennial allergic rhinitis. 2.Suffering from acute rhinitis, paranasal sinusitis, nasal polyp, hypertrophic rhinitis, deflected septum. 3.Being associated with bronchial asthma. 4.Suffering from serious disease of liver, kidney, heart, respiratory apparatus, internal secretion, or metabolism. 5.Practicing specific hyposensitization therapy. 6.Using oral medicines or nose drops such as antihistamine or anti-allergic agent, and using other medicines. 7.Daily intakes of preparations or supplements including lactic acid bacteria. 8.Daily intakes of yogurt or foods which have the effect of anti-allergy such as Tencha(sweet tea). 9.Suspected to be allergic to ingredients of the test material. 10.Being pregnant, likely to be pregnant, or breast-feeding. 11.Participants in other clinical tests like having foods or using medicines. Participants in other clinical tests like putting on cosmetics or medical application. 12.Participants or likely to be participants in other clinical tests within a month before getting consent. 13.Being interpreted unsuitable for a subject by the principal investigator.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Amelioration in subjective symptoms of perennial allergic rhinitis after 4 or 8 weeks intervention

Secondary Outcome Measures

Name	Time	Method
After 4 or 8 weeks intervention, local findings, antigen-specific IgE(house dust, Dermatophagoides pteronyssinus, Dermatophagoides farinae, night fly, animal epithelial, total IgE), questionnaires on subjective symptoms, medical interview(including findings), body weight, body height, BMI, blood pressure, pulse rate, Blood tests(leukocyte count, erythrocyte count, hemoglobin, hematocrit, platelet count, MCV, MCH, MCHC, leukocyte picture, total protein, albumin, AST(GOT), ALT(GPT), LD(LDH), total bilirubin, ALP, g-GT(g-GTP), CK(CPK), urea nitrogen(UN), uric acid level, creatinine, Na, Cl, K, Ca, total cholesterol, LDL-cholesterol, HDL-cholesterol, TG(neutral fat), fasting blood sugar, HbA1c, insulin, urinary test(protein, sugar, occult blood reaction, urobilinogen, pH, specific gravity)