The effect of a Fasting mimickINg Diet on the immune system: an exploratory study

Completed

• Conditions: gezonde proefpersonen; n.a.

• Registration Number: NL-OMON51212
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2022-04-19
• Last Update Posted: 9 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 16

Inclusion Criteria

- *18 years old
- BMI *18,5 and *25kg/m2

Exclusion Criteria

- Chronic disease or active infection
- Medication use other than contraceptive, during the last 12 weeks prior to
inclusion.
- A history of allergy
- Blood or plasma donation in the last 12 weeks prior to inclusion.
- Participation in other medical research in the last 12 weeks prior to
inclusion.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The changes in gene expression profile and pathway signaling in white blood<br /><br>cells using RNA nanostring analysis on whole blood samples. The blood samples<br /><br>are collected at 3 different time points in a fed state, fasted state and after<br /><br>the second cycle of the fasting mimicking diet. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Flow cytometry on peripheral blood mononuclear cells, including confirmation<br /><br>of gene expression profile alterations on the protein level.<br /><br>- Change in plasma concentration of IGF1, glucose and ketone bodies.<br /><br>- Evaluation of experienced side effects from FMD recorded in the toxicity<br /><br>forms in the Case report form (CRF) assessed on day 1 and 31.</p><br>