Skip to main content
MedPathMedPath Home
Clinical Trials/ISRCTN76920690
ISRCTN76920690
Completed
未知

Short and long term effect of a Very Low Calorie Diet (VLCD) with or without exercise in obese insulin-dependent type 2 diabetes mellitus patients: A randomised controlled trial

eiden University Medical Center (Netherlands)0 sites28 target enrollmentApril 5, 2011
Share to TwitterShare to FacebookShare to LinkedInShare to Reddit
ConditionsDiabetes mellitus type 2Nutritional, Metabolic, EndocrineNon-insulin-dependent diabetes mellitus

Overview

Phase
未知
Intervention
Not specified
Conditions
Diabetes mellitus type 2
Sponsor
eiden University Medical Center (Netherlands)
Enrollment
28
Status
Completed
Last Updated
9 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
April 5, 2011
End Date
TBD
Last Updated
9 years ago
Study Type
Interventional
Sex
All

Investigators

Sponsor
eiden University Medical Center (Netherlands)

Eligibility Criteria

Inclusion Criteria

  • •1\. Type 2 diabetes mellitus patients
  • •2\. Body mass index (BMI) \> 30 kg/m2 (but weight has to be greater than 90 kg to sustain a 16 week VLCD)
  • •3\. Age \> 30 years
  • •4\. Use of at least 30 units of insulin/day with or without oral blood glucose lowering agents
  • •5\. Fasting c\-peptide level \> 0\.8 ng/l and a two times rise on 1 mg glucagon (intravenous) IV

Exclusion Criteria

  • •1\. No residual insulin secretory capacity as defined by no response to a glucagon stimulation test
  • •2\. Weight above 130 kg and fasting plasma glucose \>15 mmol/l
  • •3\. Any significant chronic disease
  • •4\. Renal, hepatic or another endocrine disease
  • •5\. Use of medication known to influence lipolysis and/or glucose metabolism
  • •6\. Recent weight changes or attempts to lose weight ( \> 3 kg weight gain or loss, within the last 3 months)
  • •7\. Difficulties to insert an intravenous catheter
  • •8\. Smoking
  • •9\. Severe claustrophobia (ventilated hood)
  • •10\. Recent blood donation (within the last 3 months)

Outcomes

Primary Outcomes

Not specified

Similar Trials

Recruiting
Phase 3
Effect of intermittent very-low-calorie diet on glycemic control and cardiovascular risk factors in obese patients with type 2 diabetes mellitusDiabetes mellitus type 2ObesityDietary interventionintermittent very low calorie diettype 2 diabetes mellitusObesityCardiovascular risk factorsQuality of life
TCTR20160118001King Chulalongkorn Memorial Hospital42
Completed
Not Applicable
Effects of weight loss on obstructive sleep apnoea syndrome (OSAS): a randomised controlled trial
ISRCTN70090382Cambridge Manufacturing Company Limited (UK)60
Completed
Not Applicable
Dietary modification and diabetesType 2 diabetes.Non-insulin-dependent diabetes mellitus
IRCT2016070228742N1Shahid Beheshti University of Medical Sciences36
Not yet recruiting
Not Applicable
4 weeks of eating a diet less in calories and its effect on insulin-secretioHealth Condition 1: E663- Overweight
CTRI/2023/04/051807Christian Medical College, Vellore
Completed
Not Applicable
The TEMPO Diet Trial: Type of Energy Manipulation for Promoting optimum metabolic health and body composition in ObesityObesityCardiovascular diseaseSarcopeniaOsteoporosisNeuroendocrine functionDiet and Nutrition - ObesityMetabolic and Endocrine - Normal metabolism and endocrine development and functionMusculoskeletal - Normal musculoskeletal and cartilage development and function
ACTRN12612000651886Sydney Local Health District101