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Clinical Trials/NCT06416319
NCT06416319
Recruiting
Not Applicable

Preoperative Physical Activity Improvement With the Use of Activity Trackers in Patients Undergoing Radical Cystectomy for Bladder Cancer: A Randomized Controlled Trial (PreAct)

Universitätsmedizin Mannheim2 sites in 1 country164 target enrollmentMarch 14, 2023

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Bladder Cancer
Sponsor
Universitätsmedizin Mannheim
Enrollment
164
Locations
2
Primary Endpoint
Number of steps per day
Status
Recruiting
Last Updated
last year

Overview

Brief Summary

A bicentric, open-label randomised controlled trial (RCT) is planned to investigate whether the use of fitness wristbands in a defined preoperative period prior to radical cystectomy leads to a preoperative increase in participants' physical activity (number of steps per day) up to the day of radical cystectomy.

Detailed Description

The goal of the PreAct study is to test whether the use of fitness wristbands in a defined preoperative period prior to radical cystectomy with a daily activity goal and feedback on the achievement of this goal improves the participants' physical activity up to the day of radical cystectomy. In addition to the fitness tracker, we provide each patient with a smartphone. For each fitness tracker a separate account in a fitness application is set up for (e.g. name: tracker1.0 with the corresponding e-mail address and password). Neither the patients in the Daily activity Goal and Feedback arm nor the No Daily Activity Goal or Feedback arm receive the access data to the accounts. However, the patients in the intervention group receive the access PIN for the smartphone. On this smartphone a messaging service and the fitness application are installed. The patient thus receives, for example the wristband tracker1.0, which is registered with the corresponding access data in the fitness application of the smartphone given to them. For the entire preoperative period, the Bluetooth function on the smartphone must always stay activated so that the fitness application and the fitness tracker are continuously connected to each other. A detailed description of the timing and implementation of the intervention are described in "Study design" and "Arm and Interventions".

Registry
clinicaltrials.gov
Start Date
March 14, 2023
End Date
March 14, 2026
Last Updated
last year
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Karl-Friedrich Kowalewski

Managing Senior Physician

Universitätsmedizin Mannheim

Eligibility Criteria

Inclusion Criteria

  • Planned radical cystectomy with bilateral pelvic lymphadenectomy and one of the different forms of urinary diversion (continent vs. incontinent; orthotopic vs. heterotopic) in patients with bladder cancer
  • Participants age ≥ 18 years and capacity to consent
  • Mobile participant who is not dependent on a walking aid
  • The participant declares his or her consent to participate in this study by signing and dating the informed consent form prior to the surgical procedure

Exclusion Criteria

  • Karnofsky performance status scale ≤ 70% (with 70%: Care for self. Unable to carry on normal activity or to do active work (Ambulatory and capable of all selfcare but unable to carry out any work activities). ) (Range: 0 - 100 percent with 0 percent "participant´s death" and 100 percent "no disabilities"
  • ASA Physical Status Classification: ASA \> 3 (3: A patient with severe systemic disease)
  • ASA 1, 2, 3 if acute or chronic diseases of the musculoskeletal system or the central nervous system are involved that result in a symptomatic restriction of motor and / or, in the last case, neurological function (healing ruptures and fractures, Parkinson's disease, multiple sclerosis, etc.)
  • Emergency intervention

Outcomes

Primary Outcomes

Number of steps per day

Time Frame: Participants' daily step count is recorded on the day of surgery when the fitness tracker is put down.

Average daily step count measured by the fitness tracker during the period of prehabilitation 7 to 10 days before surgery.

Secondary Outcomes

  • Operating time(On the day of surgery)
  • Reoperation rate(On postoperative day 90 if occured)
  • Blod loss(On the day of surgery)
  • Length of stay in the intensive care unit (ICU)(On postoperative day 90 if occured)
  • Total number of steps(Participants' total number of steps is recorded on the day of surgery when the fitness tracker is put down.)
  • Patient Reported Outcome Measures (PROMs)(On the day of randomization at the premedication appointment and on the day of discharge which is on average 2 weeks after the surgery and postoperative day 30 and 90)
  • Readmission rate(On postoperative day 90 if occured)
  • Postoperative physical activity(Morning of postoperative day 4 at 7 PM)
  • Postoperative Complications(On postoperative day 30 and 90)
  • Required transfusion of blood products(On the day of surgery)
  • Length of hospital stay (LOS)(On the day of discharge which is on average 2 weeks after the surgery)
  • Feasibility of the planned urinary diversion(On the day of surgery)
  • Conversion rate(On the day of surgery)

Study Sites (2)

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