TCTR20200604013已完成2 期
Effects of mineralocorticoid receptor antagonist on intradialytic hypertension: a multicenter, double-blind, randomized crossover study
ampang hospital0 个研究点目标入组 49 人开始时间: 2020年6月4日最近更新:
适应症
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 49
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 Years 至 90 Years（—）
- 性别
- All
入选标准
- •1. ESRD patients (defined by Kidney Disease Initiative Global Outcome (KDIGO)
- •Guideline 2012) requiring chronic hemodialysis
- •2. Hemodialysis vintage more than 12 weeks
- •3. Hemodialysis with at least 2 sessions per week
- •4. History of intradialytic hypertension (defined by an increase in systolic blood pressure >15 mmHg or mean arterial pressure >10 mmHg during hemodialysis) at least 30% of their dialysis sessions during the past 12 weeks
排除标准
- •1. Serum potassium >5.5 mEq/L or <2.5 mEq/L
- •2. Active cardiac, pulmonary or hepatobiliary tract disease
- •3. Active infection or sepsis
- •4. Active malignancy
- •5. Cirrhosis
- •6. Prior treatment with spironolactone in past 4 weeks
- •7. Contraindication to spironolactone
- •8. Interdialytic weight gain more than 6%
研究者
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