Micromanaging Human Sleep Physiology to Treat Sleep Apnea and Other Disorders

Not Applicable

Not yet recruiting

• Conditions: Sleep Apnea Obstructive (OSA)

• Registration Number: NCT06926036
• Lead Sponsor: Northwestern University

Brief Summary

This study will examine whether a combination of breathing training during wake and targeted reactivation of the training during sleep can induce breathing changes during sleep and subsequent cognitive benefits during wake.

Participants with obstructive sleep apnea (who have not yet been treated for sleep apnea) will be recruited. Participants will engage in breath training for one week in their own homes and to record their sleep at home using commercially available mobile devices and subsequently have their sleep monitored for one night of polysomnography recordings plus targeted reactivation in a laboratory setting.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2025-03-05
• Status Verified: 2025-04
• Study Start: 2025-04
• Study First Submitted QC: 2025-04-07
• Last Update Submitted: 2025-04-07
• Study First Posted: 2025-04-13
• Last Update Posted: 2025-04-13
• Primary Completion: 2027-04
• Study Completion: 2027-04

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

1. Right-handed, English-speaking adults, 18-60 years old who report normal hearing during sleep
2. Participants with suspected obstructive sleep apnea (OSA) (including those who have been diagnosed by a physician and those whose self-reported symptoms of OSA on the STOP-BANG questionnaire classify them as being "individuals with intermediate to high risk".
3. No report of any other sleep disorder besides OSA.
4. No report of any neurological or cardiometabolic diseases or disorders.
5. Not currently under active treatment for sleep apnea.
6. BMI ≤ 40.

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Apnea-Hypopnea Index (AHI)	Day 1	AHI indexes the severity of OSA on the night of the study.
Respiratory event duration	Day 1	The duration of a hypopnea or apnea on the night of the study.

Trial Locations

Locations (1)

Northwestern University; 🇺🇸 Chicago, Illinois, United States