Dietary Iron Requirements

Not yet recruiting

• Conditions: Iron Absorption

• Registration Number: NCT07139821
• Lead Sponsor: Pennington Biomedical Research Center

Brief Summary

Dietary Reference Intakes (DRIs) for iron are based on a relatively small number of studies in European populations. This research study will determine iron needs in a representative sample of adults living in the US using the iron isotope dilution technique. Following administration and equilibration of a stable iron isotope, participants will be followed for a 12 week study period. Blood will be collected every 4 weeks and the isotopic composition will be determined. Results will help update dietary iron guidelines making sure they better match the specific needs of the US population.

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-08
• Study First Submitted: 2025-08-07
• Study First Submitted QC: 2025-08-21
• Last Update Submitted: 2025-08-21
• Study First Posted: 2025-08-24
• Last Update Posted: 2025-08-24
• Study Start: 2025-09-01
• Primary Completion: 2028-08-01
• Study Completion: 2029-05-31

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

• Males and premenopausal females age 18-50 y
• Previously participated in an iron stable isotope study or willing to consume an oral stable iron isotope and undergo a one-year equilibration period
• Willing to refrain from iron-containing supplements for the duration of the study
• Willing to refrain from tobacco smoking for the duration of the study
• Have not donated blood 3 months prior to the start of the study and willing to refrain from donating blood for the duration of the study
• Willing to have blood stored for future use
• Able and willing to comply with study requirements and consent to participate

Exclusion Criteria

• Females: pregnant or lactating or plans to become pregnant during the study period
• Inability to provide informed consent and engage in informed consent procedures
• Plans to relocate outside the study area

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Iron isotope composition in blood	12 weeks	Tracer-to-tracee rate in venous blood samples collected at multiple time points

Trial Locations

Locations (2)

LSU Pennington Biomedical Research Center; 🇺🇸 Baton Rouge, Louisiana, United States

Cornell University; 🇺🇸 Ithaca, New York, United States