Role of host cell DNA Methylation Analysis in predicting non-Regression or regression of high-grade anal Intraepithelial NEoplasia in HIV+ men (MARINE) trial

Amsterdam UMC, location AMC0 个研究点目标入组 200 人开始时间: 待定最近更新: 2024年2月28日

适应症

试验速览

暂无简介。

•HIV+ patients of at least 18 years of age that are cisgender men, transgender men or
•transgender women and who have sex with men (further referred to as HIV+ MSM);
•-- Transgender men and women are an often neglected group in research, but
•also at risk for anal HPV . Because of the comparable risk profile, we
•assume that HIV+ transgender men and women who have sex with men have
•a comparable chance of progression to anal cancer as cisgender HIV+MSM.
•- histopathological confirmed HGAIN (=1 lesion);
•- satisfactory HRA at baseline, i.e. visualisation of entire transformation zone with
•biopsies of all lesions;

•- HGAIN covering >50% of the circumference of the anal canal (progression to cancer
•of these patients is estimated as high and therefore withholding treatment would be unethical);
•- clinical suspicion for anal cancer, defined as palpable abnormalities at DARE and
•suspicion of invasion at MRI;
•- histopathological diagnosis of anal cancer;
•- history of anal cancer;
•- previous HPV vaccination (including participants of the VACCAIN-T and VACCAIN-P trial);
•- concomitant cancer;
•- insufficient Dutch or English language skills.

发起方

Amsterdam UMC, location AMC