Effect of an Internet-based At-home Physical Training Protocol on Quality of Life, Fatigue, Functional Performance, Aerobic Capacity and Muscle Strength in Multiple Sclerosis Patients
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Multiple Sclerosis
- Sponsor
- University of Erlangen-Nürnberg
- Enrollment
- 126
- Primary Endpoint
- Change in Hamburg Quality of Life Questionnaire for Multiple Sclerosis (HAQUAMS)
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
In this randomised controlled trial, the feasibility and effectiveness of an internet-based exercise intervention including progressive strength and endurance training (e-training) for PwMS was investigated. Primary outcome was health-related quality of life, secondary outcomes were muscle strength, aerobic capacity and lung function, physical activity and fatigue.
Investigators
Prof. Dr. Klaus Pfeifer
Prof. Dr.
Friedrich-Alexander-Universität Erlangen-Nürnberg
Eligibility Criteria
Inclusion Criteria
- •diagnosed Multiple Sclerosis (McDonald criteria),
- •an EDSS score of less than or equal to 4.0,
- •not less than 4 weeks of clinical stability prior to inclusion in the study,
- •access to the internet.
- •the taking of immunotherapeutic agents was not relevant and not monitored
Exclusion Criteria
- •primary progressive multiple sclerosis
- •clinically relevant internal disease, especially cardiovascular or pulmonary disease, metabolic and orthopedic diseases
Outcomes
Primary Outcomes
Change in Hamburg Quality of Life Questionnaire for Multiple Sclerosis (HAQUAMS)
Time Frame: Assessments took place at baseline and at 3 months
38 items generate the subscales of fatigue/thinking, mobility of the lower/upper extremities, communication and mood. The HAQUAMS total score is calculated from a mean of the subscales, providing a total score between 1 and 5. Higher scores in HAQUAMS indicate lower levels in HRQoL. The primary outcome will be the change over time from baseline to month 3.
Secondary Outcomes
- Aerobic capacity(Assessments took place at baseline and after 3 and 6 months)
- Würzburg Fatigue Scale (WEIMuS)(Assessments took place at baseline, at 3 and 6 months)
- Muscle strength lower extremities(Assessments took place at baseline and after 3 and 6 months)
- Forced vital capacity(Assessments took place at baseline and after 3 and 6 months)
- Physical activity(Assessments took place at baseline and after 3 and 6 months)
- Peak expiratory flow(Assessments took place at baseline and after 3 and 6 months)