Healing Effect of Tea Tree Oil on Burn

Not Applicable

Completed

• Conditions: Burn
• Interventions: Drug: tea tree oil ointment

• Registration Number: NCT07149844
• Lead Sponsor: Alexandria University

Brief Summary

Tea tree oil (TTO) has been recognized for its effectiveness in treating infected burns, insect bites, and promoting wound healing. This clinical study aimed to compare the impact of Tea tree oil dressings versus conventional ones in the healing process of second degree burns wounds.

Detailed Description

This quasi-experimental comparative controlled clinical trial was conducted at the Burn Unit of Ras-Elteen General Hospital in Alexandria, Egypt. A purposive sample of 30 adult patients with second-degree burns on the chest, abdomen, upper limbs (excluding hands), and lower limbs (excluding feet) was enrolled from the Emergency and Outpatient Departments. Participants were sequentially assigned to two equal groups:

Control group (n=15): Received conventional dressings (sterile gauze with silver sulfadiazine).

Study group (n=15): Received topical 10% tea tree oil (TTO) ointment applied directly to wounds.Wounds were cleansed with sterile normal saline (0.9%), and non-viable tissue was debrided.

Dressings were changed every other day unless soiled or damp. Burns near joints were maintained in functional positions.Wound assessment was performed on days 7, 14, and 21 post-treatment

Study Timeline

• Study Start: 2021-07-02
• Primary Completion: 2023-07-22
• Study Completion: 2023-09-22
• Status Verified: 2025-08
• Study First Submitted: 2025-08-18
• Study First Submitted QC: 2025-08-24
• Last Update Submitted: 2025-08-24
• Study First Posted: 2025-09-02
• Last Update Posted: 2025-09-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Patient willing to participate and communicate
• Newly admitted with recent 2nd-degree burns (superficial or deep) involving ≤10% of TBSA
• Length of hospital stay of 10 days

Exclusion Criteria

Any associated illnesses that may affect wound healing, such as:

• Diabetes mellitus (DM)
• Immune disorders
• Pre-existing skin conditions (e.g., eczema)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
conventional dressing	tea tree oil ointment	Conventional dressing: Is the routine study hospital's burn dressing technique, utilizing sterile topical gauze dressing that is impregnated with or laid over a topical antibacterial, silver sulphadiazin dressing secured with adhesive tape.

Primary Outcome Measures

Name	Time	Method
morphological wound changes	3 weeks	assessment of: wound bed, wound margin: color, size, depth, presence of exudates: its amount, color, odor, and type, or scare, edema and granulation tissue formation; in addition to assessment of the wound's surrounding skin condition for: erythema, hotness, tenderness, swelling, separation of deep tissues, fever and peri-wound skin laceration. Each item was rated to score on 2 points Likert scale: 0 = not present and 1= Present. A total score of every patient in both groups was summed up and converted into percent score.

Trial Locations

Locations (1)

Ras Eltin Hospital; 🇪🇬 Alexandria, Egypt