Efficacy of adjunctive alpha TRANSCRANIAL ALTERNATING CURRENT STIMULATION in Obsessive Compulsive Disorder as measured by functional MAGNETIC RESONANCE IMAGING:A sham controlled study.

OCD is a major mental health condition accompanied by severe distress, high levels of disability, and disruption of the person’s social and occupational functioning.In the functional neuroanatomy of OCD, a critical role has been assigned to the orbitofrontal cortex (OFC), a brain region crucially involved in reward-guided learning and decision making.Transcranial alternating current stimulation (tACS) is a form of non-invasive brain stimulation which modulates neural oscillations in humans by application of weak electric current to the scalp.Current medication and behaviour therapies in OCD, although effective in most patients, fail to provide adequate benefit in many patients most severely affected.Although studies done on TMS and tDCS have shown promising results, the opinion about their efficacy on OCD as a treatment modality remains equivocal.The past studies using tACS on OCD population to be effective but it includes only case series, case reports and studies on non-clinical population.To the best of our knowledge, no study has been done targeting the OFC using tACS in OCD population, hence this study intends to assess the efficacy of tACS on OFC in OCD population.