Effects of a Multiple Component Training Program on Muscles, Maximal Muscle Strength, Endurance and Functional Performance in Adults With Myotonic Dystrophy Type 1: A Pilot Study
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Cynthia Gagnon
- Enrollment
- 11
- Locations
- 1
- Primary Endpoint
- Change in maximal muscle strength in the knee extensors measured by quantified muscle testing
Study Overview
Brief Summary
A strength and endurance training program was conducted in adults with myotonic dystrophy type 1 (DM1). Participants underwent a 12-week/18-session supervised training program consisted of 6 exercises: elbow flexion/extension, shoulder horizontal adduction, leg press, and knee flexion/extension. To offer a complete training program aimed at improving function it was divided: the first 6 weeks were dedicated to strength-training, whereas the following weeks focused on endurance-training. To evaluate the effects of the training program, participants completed maximal strength, endurance and functional evaluations. Volunteers could also add a muscle biopsy at the beginning and the end of the program to evaluate physiological parameters.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Supportive Care
- Masking
- None
Eligibility Criteria
- Ages
- 20 Years to 60 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Adults with DM1
- •Walk without technical aid
- •Muscle impairment rating scale (MIRS) of 3 or 4
Exclusion Criteria
- •Severe musculoskeletal disorders
- •Any medical contraindication to physical exercise
- •Any medical contraindication to muscle biopsies for the biopsy volunteers
Arms & Interventions
Training program
12-week strength and endurance training program
Intervention: Training program (Other)
Outcomes
Primary Outcomes
Change in maximal muscle strength in the knee extensors measured by quantified muscle testing
Time Frame: Before and after the 12-week training program
Changes in knee extensor maximal muscle strength evaluated by quantified muscle testing with a handheld dynamometer.
Secondary Outcomes
- Changes in muscle biopsy-leucocyte infiltration(Before and after the 12-week training program for volunteers)
- Change in 6 minute walking test disance(Before and after the 12-week training program)
- Changes in quality of life measured by the 36-Item Short Form Survey (SF-36)(Before and after the 12-week training program)
- Changes in muscle biopsy-muscle fiber size(Before and after the 12-week training program for volunteers)
- Changes in functional capacity measured by the UQAM-YMCA test(Before and after the 12-week training program)
- Changes in sprint capacity measured by the Running-base anaerobic sprint test(Before and after the 12-week training program)
- Changes in stumbles and falls measured by the Falls efficacy scale(Before and after the 12-week training program)
- Changes in daytime sleepiness measured by the Daytime sleepiness scale (Epworth Sleepiness Scale)(Before and after the 12-week training program)
- Changes in life habits measured by questionnaire(Before and after the 12-week training program)
- Changes in muscle biopsy-proportion of centrally nuclated fibers(Before and after the 12-week training program for volunteers)
- Changes in fatigue measured by the Fatigue severity scale(Before and after the 12-week training program)
- Changes in muscle biopsy-muscle fiber typing(Before and after the 12-week training program for volunteers)
Investigators
Cynthia Gagnon
Sponsor-Investigator
Université de Sherbrooke