Validation of novel PET tracer [11C]-GMOM: Assessment of dosimetry, biodistribution, and specific binding in healthy volunteers - Validation of novel PET tracer [11C]-GMOM

Vrije Universiteit Medisch Centrum0 个研究点目标入组 14 人开始时间: 待定最近更新: 2024年4月29日

适应症

试验速览

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•- Men and women;
•- Age between 18-40 years;
•- Good physical health evaluated by medical history, physical (including neurological) examination and screening laboratory tests (Haemoglobin (Hb) must be 8 mmol \ litre at the time of the screening for males and 7 mmol \ litre for females);
•- Weight 50 kg;
•- Never mentally ill according to Research Diagnostic Criteria (RDC);
•- A negative pregnancy test must be obtained for all females within 48 hours before starting the PET scan;- Normal MRI scan as evaluated by a neuroradiologist;
•- Written informed consent of the subject;

•- (History of) Any psychiatric or neurological disorder (DSM-IV criteria);
•- Coronary heart disease;
•- (History of) Alcohol and/or drug abuse (DSM-IV criteria);
•- Any clinical significant abnormality of any clinical laboratory test, including drug screening;
•- Any condition that may interfere with MRI scanning, e.g. metal objects in or around the body or claustrophobia;
•- Blood donation or substantial blood loss within 3 months before the PET scan;
•- Intake of investigational medication within 30 days prior to the start of this study;
•- Pregnancy;
•- Smoking;

发起方