A Study to Investigate the Safety and Efficacy of ABBV-105 Alone or in Combination With Upadacitinib (ABBV-599 Combination) in Participants With Active Rheumatoid Arthritis
- Conditions
- Rheumatoid Arthritis (RA)
- Interventions
- Registration Number
- NCT03682705
- Lead Sponsor
- AbbVie
- Brief Summary
This was a phase 2 study to evaluate the safety and efficacy of elsubrutinib (ELS) and ABBV-599 (ELS plus upadacitinib \[UPA\]) vs placebo on a background of conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs) for the treatment of signs and symptoms of rheumatoid arthritis (RA) at 12 weeks in biological disease-modifying anti-rheumatic drugs (bDMARD)-inadequate response (bDMARD-IR) or bDMARD-intolerant participants with moderately to severely active RA and to define optimal dose for further development.
- Detailed Description
This was a 12-week, randomized, double-blind, parallel-group, Phase 2, dose exploratory, multicenter study. Participants who met eligibility criteria were randomized in a 3:2:2:2:2:1 ratio to 1 of 6 treatment groups: ABBV-599 \[UPA 15 mg/ELS 60 mg\]); ELS 60 mg/UPA placebo; ELS 20 mg/UPA placebo; ELS 5 mg/UPA placebo; UPA 15 mg/ELS placebo; and ELS placebo/UPA placebo. The study included a 35-day maximum screening period and a 12-week treatment period with 30-day follow-up.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 242
-
Diagnosis of rheumatoid arthritis (RA) for ≥ 3 months based on the 2010 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) classification criteria for RA
-
Participant meets the following minimum disease activity criteria:
- ≥ 6 swollen joints (based on 66 joint counts) and ≥ 6 tender joints (based on 68 joint counts) at Screening and Baseline Visits
- High-sensitivity C-reactive protein (hsCRP) ≥ 3 mg/L (central lab) at Screening Visit
-
Participants must have been treated for ≥ 3 months with ≥ 1 biologic disease-modifying anti-rheumatic drug (bDMARD) therapy but continue to exhibit active RA or had to discontinue due to intolerability or toxicity, irrespective of treatment duration
-
Participants must have been receiving conventional synthetic disease-modifying anti-rheumatic drug (csDMARD) therapy ≥ 3 months and on a stable dose for ≥ 4 weeks prior to the first dose of study drug
-
Participants must have discontinued all bDMARDs prior to the first dose of study drug
- Participant has prior exposure to any Janus Kinase (JAK) inhibitor for greater than 2 weeks (including but not limited to upadacitinib, tofacitinib, baricitinib, and filgotinib). A washout period of ≥ 30 days is required for any JAK inhibitor prior to the first dose of study drug.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description UPA 15 mg/ELS 60 mg Elsubrutinib 15 mg film-coated upadacitinib tablet once a day by mouth for 12 weeks; 60 mg elsubrutinib capsule once a day by mouth for 12 weeks ELS 60 mg/UPA placebo Elsubrutinib 60 mg elsubrutinib capsule once a day by mouth for 12 weeks; placebo film-coated tablet for upadacitinib once a day by mouth for 12 weeks ELS placebo/UPA placebo Placebo for elsubrutinib Placebo capsule for elsubrutinib once a day by mouth for 12 weeks; placebo film-coated tablet for upadacitinib once a day by mouth for 12 weeks ELS placebo/UPA placebo Placebo for upadacitinib Placebo capsule for elsubrutinib once a day by mouth for 12 weeks; placebo film-coated tablet for upadacitinib once a day by mouth for 12 weeks UPA 15 mg/ELS placebo Placebo for elsubrutinib 15 mg film-coated upadacitinib tablet once a day by mouth for 12 weeks; placebo capsule for elsubrutinib once a day by mouth for 12 weeks ELS 5 mg/UPA placebo Elsubrutinib 5 mg elsubrutinib capsule once a day by mouth for 12 weeks; placebo film-coated tablet for upadacitinib once a day by mouth for 12 weeks ELS 60 mg/UPA placebo Placebo for upadacitinib 60 mg elsubrutinib capsule once a day by mouth for 12 weeks; placebo film-coated tablet for upadacitinib once a day by mouth for 12 weeks ELS 20 mg/UPA placebo Placebo for upadacitinib 20 mg elsubrutinib capsule once a day by mouth for 12 weeks; placebo film-coated tablet for upadacitinib once a day by mouth for 12 weeks ELS 5 mg/UPA placebo Placebo for upadacitinib 5 mg elsubrutinib capsule once a day by mouth for 12 weeks; placebo film-coated tablet for upadacitinib once a day by mouth for 12 weeks ELS 20 mg/UPA placebo Elsubrutinib 20 mg elsubrutinib capsule once a day by mouth for 12 weeks; placebo film-coated tablet for upadacitinib once a day by mouth for 12 weeks UPA 15 mg/ELS 60 mg Upadacitinib 15 mg film-coated upadacitinib tablet once a day by mouth for 12 weeks; 60 mg elsubrutinib capsule once a day by mouth for 12 weeks UPA 15 mg/ELS placebo Upadacitinib 15 mg film-coated upadacitinib tablet once a day by mouth for 12 weeks; placebo capsule for elsubrutinib once a day by mouth for 12 weeks
- Primary Outcome Measures
Name Time Method Change From Baseline in Disease Activity Score 28 C-reactive Protein [DAS28-CRP]) at Week 12 Baseline, Week 12 The DAS28-CRP is a composite index used to assess rheumatoid arthritis disease activity, calculated based on the tender joint count (out of 28 evaluated joints), swollen joint count (out of 28 evaluated joints), Patient's Global Assessment of Disease Activity (0-100 mm), and high-sensitivity C-reactive protein (hsCRP; in mg/L). Scores on the DAS28-CRP range from 0 to approximately 10, where higher scores indicate more disease activity. A negative change from baseline indicates improvement in disease activity.
- Secondary Outcome Measures
Name Time Method Percentage of Participants Achieving Clinical Remission (CR) Based on Disease Activity Score 28 C-reactive Protein [DAS28-CRP]) at Week 12 At Week 12 The DAS28-CRP is a composite index used to assess rheumatoid arthritis disease activity, calculated based on the tender joint count (out of 28 evaluated joints), swollen joint count (out of 28 evaluated joints), Patient's Global Assessment of Disease Activity (0-100 mm), and high-sensitivity C-reactive protein (hsCRP; in mg/L). Scores on the DAS28-CRP range from 0 to approximately 10, where higher scores indicate more disease activity. Clinical remission (CR) based on DAS28 (CRP) is defined as achieving a DAS28 (CRP) of less than 2.6.
Change From Baseline in Morning Stiffness Severity Baseline, Week 2, Week 4, Week 8, and Week 12 Morning stiffness severity was assessed by a numeric rating-scale (NRS). Participants rated the severity of morning stiffness during the past week from 0 to 10 with 0 representing "not severe" and 10 "very severe". Negative values indicate improvement from baseline.
Change From Baseline in Simplified Disease Activity Index (SDAI) Baseline, Week 2, Week 4, Week 8, and Week 12 The SDAI is a validated measure of rheumatoid arthritis disease activity. Twenty-eight tender joint counts, 28 swollen joint counts, global disease activity assessed by the participant on a visual analogue scale from 0 to 10 (cm), global disease activity assessed by an investigator on a visual analogue scale from 0 to 10 (cm), and serum levels of C-reactive protein (CRP; mg/dL) were included in the SDAI score. Scores on the SDAI range from 0 to 86.with higher scores indicating higher disease activity. A negative change from baseline indicates improvement in disease activity.
Change From Baseline in Clinical Disease Activity Index (CDAI) Baseline, Week 2, Week 4, Week 8, and Week 12 The CDAI is a composite index for assessing disease activity based on the summation of the total tender joint count (out of 28 evaluated joints), swollen joint count (out of 28 evaluated joints), patient global assessment of disease activity measured on a VAS from 0 to 10 cm, and physician global assessment of disease activity measured on a VAS from 0 to 10 cm. The total CDAI score ranges from 0 to 78 with higher scores indicating higher disease activity. A negative change from baseline indicates improvement in disease activity.
Percentage of Participants Achieving Complete Remission (CR) Based on Clinical Disease Activity Index (CDAI) Criteria Week 2, Week 4, Week 8, and Week 12 The CDAI is a composite index for assessing disease activity based on the summation of the total tender joint count (out of 28 evaluated joints), swollen joint count (out of 28 evaluated joints), patient global assessment of disease activity measured on a VAS from 0 to 10 cm, and physician global assessment of disease activity measured on a VAS from 0 to 10 cm. The total CDAI score ranges from 0 to 78 with higher scores indicating higher disease activity. Complete Remission (CR) based on CDAI is defined as achieving a CDAI of less than or equal to 2.8.
Percentage of Participants Achieving Low Disease Activity (LDA) Based on Disease Activity Score 28 C-reactive Protein [DAS28-CRP]) at Week 12 At Week 12 The DAS28-CRP is a composite index used to assess rheumatoid arthritis disease activity, calculated based on the tender joint count (out of 28 evaluated joints), swollen joint count (out of 28 evaluated joints), Patient's Global Assessment of Disease Activity (0-100 mm), and high-sensitivity C-reactive protein (hsCRP; in mg/L). Scores on the DAS28-CRP range from 0 to approximately 10, where higher scores indicate more disease activity. Low Disease Activity (LDA) based on DAS28 (CRP) is defined as achieving a DAS28 (CRP) of less than or equal to 3.2.
Percentage of Participants Achieving Low Disease Activity (LDA) Based on Clinical Disease Activity Index (CDAI) Criteria Week 2, Week 4, Week 8, and Week 12 The CDAI is a composite index for assessing disease activity based on the summation of the total tender joint count (out of 28 evaluated joints), swollen joint count (out of 28 evaluated joints), patient global assessment of disease activity measured on a VAS from 0 to 10 cm, and physician global assessment of disease activity measured on a VAS from 0 to 10 cm. The total CDAI score ranges from 0 to 78 with higher scores indicating higher disease activity. Low Disease Activity (LDA) based on CDAI is defined as achieving a CDAI of less than or equal to 10.
Percentage of Participants With an American College of Rheumatology 20% (ACR20) Response Baseline, Week 2, Week 4, Week 8, and Week 12 Participants who met the following 3 conditions for improvement from baseline were classified as meeting the American College of Rheumatology 20% response (ACR20) criteria:
1. ≥ 20% improvement in 68-tender joint count
2. ≥ 20% improvement in 66-swollen joint count and
3. ≥ 20% improvement in at least 3 of the 5 following parameters:
* Patient's Assessment of Pain (Visual Analog Scale \[VAS\])
* Patient's Global Assessment of Disease Activity (PtGA)
* Physician's Global Assessment of Disease Activity (PhGA)
* Health Assessment Questionnaire Disability Index (HAQ-DI)
* High-sensitivity C-reactive protein (hsCRP)Percentage of Participants With an American College of Rheumatology 50% (ACR50) Response Baseline, Week 2, Week 4, Week 8, and Week 12 Participants who met the following 3 conditions for improvement from baseline were classified as meeting the American College of Rheumatology 50% response (ACR50) criteria:
1. ≥ 50% improvement in 68-tender joint count
2. ≥ 50% improvement in 66-swollen joint count and
3. ≥ 50% improvement in at least 3 of the 5 following parameters:
* Patient's Assessment of Pain (Visual Analog Scale \[VAS\])
* Patient's Global Assessment of Disease Activity (PtGA)
* Physician's Global Assessment of Disease Activity (PhGA)
* Health Assessment Questionnaire Disability Index (HAQ-DI)
* High-sensitivity C-reactive protein (hsCRP)Percentage of Participants With an American College of Rheumatology 70% (ACR70) Response Baseline, Week 2, Week 4, Week 8, and Week 12 Participants who met the following 3 conditions for improvement from baseline were classified as meeting the American College of Rheumatology 70% response (ACR70) criteria:
1. ≥ 70% improvement in 68-tender joint count
2. ≥ 70% improvement in 66-swollen joint count and
3. ≥ 70% improvement in at least 3 of the 5 following parameters:
* Patient's Assessment of Pain (Visual Analog Scale \[VAS\])
* Patient's Global Assessment of Disease Activity (PtGA)
* Physician's Global Assessment of Disease Activity (PhGA)
* Health Assessment Questionnaire Disability Index (HAQ-DI)
* High-sensitivity C-reactive protein (hsCRP)Change From Baseline in Tender Joint Count 68 (TJC68) Baseline, Week 2, Week 4, Week 8, and Week 12 Sixty-eight joints were assessed for tenderness by physical examination. Pain or tenderness of each joint was classified as present (1) or absent (0), for a total possible score of 0 (0 joints with tenderness) to 68 (worst possible score/68 joints with tenderness). Negative values indicate improvement from baseline.
Change From Baseline in Participant's Assessment of Pain (Visual Analog Scale [VAS]) Baseline, Week 2, Week 4, Week 8, and Week 12 Participants rated their pain on a visual analogue scale (VAS) of 0 to 100 (mm), with 0 representing no pain and 100 representing the worst possible pain. Negative values indicate improvement from baseline.
Change From Baseline in Physician's Global Assessment of Disease Activity (PhGA) Baseline, Week 2, Week 4, Week 8, and Week 12 The physician assessed a participant's disease activity at the time of the visit using a Physician's Global Assessment of Disease visual analogue scale (VAS). The range is 0 to 100 mm, with 0 representing no disease activity and 100 representing severe disease activity. Negative values indicate improvement from baseline.
Change From Baseline in High-Sensitivity C-reactive Protein (hsCRP) Baseline, Week 2, Week 4, Week 8, and Week 12 C-reactive protein is a blood test marker for inflammation in the body, and levels rise in response to inflammation. A negative change from baseline in indicates improvement.
Change From Baseline in Disease Activity Score 28 C-reactive Protein [DAS28-CRP]) Baseline, Week 2, Week 4, Week 8, and Week 12 The DAS28-CRP is a composite index used to assess rheumatoid arthritis disease activity, calculated based on the tender joint count (out of 28 evaluated joints), swollen joint count (out of 28 evaluated joints), Patient's Global Assessment of Disease Activity (0-100 mm), and high-sensitivity C-reactive protein (hsCRP; in mg/L). Scores on the DAS28-CRP range from 0 to approximately 10, where higher scores indicate more disease activity. A negative change from baseline indicates improvement in disease activity.
Change From Baseline in Disease Activity Score 28 Erythrocyte Sedimentation Rate (DAS28- ESR) Baseline, Week 2, Week 4, Week 8, and Week 12 The DAS28-ESR is a validated index of rheumatoid arthritis disease activity. Twenty-eight tender joint counts, 28 swollen joint counts, the erythrocyte sedimentation rate (ESR; mm/hour), and the participant's assessment of global disease activity (on a visual analog scale \[VAS\] from 0 to 100 mm) are included in the DAS28 -ESR score. Scores on the DAS28-ESR range from 0 to 10; higher scores indicate more disease activity.
Change From Baseline in Swollen Joint Count 66 (SJC66) Baseline, Week 2, Week 4, Week 8, and Week 12 Sixty-six joints were assessed for swelling by physical examination. Swelling of each joint was classified as present (1) or absent (0), for a total possible score of 0 (0 joints with swelling) to 66 (worst possible score/66 joints with swelling). Negative values indicate improvement from baseline.
Change From Baseline in Patient's Global Assessment of Disease Activity (PGA) Baseline, Week 2, Week 4, Week 8, and Week 12 Participants rated their disease activity for the past 24 hours using a Patient's Global Assessment of Disease Activity Global visual analogue scale (VAS). The range is 0 to 100 mm, with 0 representing no disease activity and 100 representing severe disease activity. Negative values indicate improvement from baseline.
Change From Baseline in Health Assessment Questionnaire Disability Index (HAQ-DI) Baseline, Week 2, Week 4, Week 8, and Week 12 The Health Assessment Questionnaire - Disability Index is a patient-reported questionnaire that measures the degree of difficulty a person has in accomplishing tasks in 8 functional areas (dressing, arising, eating, walking, hygiene, reaching, gripping, and errands and chores) over the past week. Participants assessed their ability to do each task on a scale from 0 (without any difficulty) to 3 (unable to do). Scores were averaged to provide an overall score ranging from 0 to 3, where 0 represents no disability and 3 represents very severe, high-dependency disability. A negative change from baseline in the overall score indicates improvement.
Percentage of Participants Achieving Minimal Clinically Important Difference (MCID) in Change From Baseline in Health Assessment Questionnaire Disability Index (HAQ-DI) Baseline, Week 2, Week 4, Week 8, and Week 12 The Health Assessment Questionnaire - Disability Index is a patient-reported questionnaire that measures the degree of difficulty a person has in accomplishing tasks in 8 functional areas (dressing, arising, eating, walking, hygiene, reaching, gripping, and errands and chores) over the past week. Participants assessed their ability to do each task on a scale from 0 (without any difficulty) to 3 (unable to do). Scores were averaged to provide an overall score ranging from 0 to 3, where 0 represents no disability and 3 represents very severe, high-dependency disability. The minimal clinically important difference (MCID) in HAQ-DI is defined as change from Baseline ≤ -0.22 for rheumatoid arthritis.
Percentage of Participants Achieving American College of Rheumatology/European League Against Rheumatism (EULAR) Boolean Remission Baseline, Week 2, Week 4, Week 8, and Week 12 The EULAR Boolean-based definition of remission is as follows: at any time point, a participant must satisfy all of the following: tender joint count ≤1, swollen joint count ≤1, C-reactive protein ≤1 mg/dl and Patient Global Assessment (PGA) ≤1 (on a 0-10 scale).
Trial Locations
- Locations (115)
Tekton Research, Inc. /ID# 167475
🇺🇸Austin, Texas, United States
Institute of Arthritis Researc /ID# 170694
🇺🇸Idaho Falls, Idaho, United States
DM Clinical Research /ID# 167444
🇺🇸Tomball, Texas, United States
Great Lakes Clinical Trials /ID# 167471
🇺🇸Chicago, Illinois, United States
Clinical Investigation Specialists - Skokie /ID# 167468
🇺🇸Skokie, Illinois, United States
Amarillo Ctr for Clin Research /ID# 200484
🇺🇸Amarillo, Texas, United States
SW Rheumatology Res. LLC /ID# 167383
🇺🇸Mesquite, Texas, United States
St. Joseph Heritage Healthcare /ID# 167379
🇺🇸Fullerton, California, United States
Ocean Rheumatology /ID# 170673
🇺🇸Toms River, New Jersey, United States
June DO, PC /ID# 170670
🇺🇸Lansing, Michigan, United States
Trinity Universal Res Assoc /ID# 209252
🇺🇸Carrollton, Texas, United States
DJL Clinical Research, PLLC /ID# 167374
🇺🇸Charlotte, North Carolina, United States
West Texas Clinical Research /ID# 205732
🇺🇸Lubbock, Texas, United States
Clayton Medical Associates dba Saint Louis Rheumatology /ID# 170650
🇺🇸Saint Louis, Missouri, United States
Marietta Memorial Hospital /ID# 210968
🇺🇸Marietta, Ohio, United States
Tidewater Physicians Medical Center /ID# 210884
🇺🇸Newport News, Virginia, United States
New Horizons Clinical Research /ID# 170862
🇺🇸Blue Ash, Ohio, United States
Credit Valley Rheumatology /ID# 202124
🇨🇦Mississauga, Ontario, Canada
Western Washington Arthritis C /ID# 205821
🇺🇸Bothell, Washington, United States
Manitoba Clinic /ID# 202126
🇨🇦Winnipeg, Manitoba, Canada
UZ Leuven /ID# 201927
🇧🇪Leuven, Belgium
CIADS Research Co Ltd /ID# 202125
🇨🇦Winnipeg, Manitoba, Canada
Mount Sinai Hosp.-Toronto /ID# 202652
🇨🇦Toronto, Ontario, Canada
ClinicMed Daniluk, Nowak Sp.j. /ID# 212576
🇵🇱Białystok, Podlaskie, Poland
Malopolskie Centrum Kliniczne /ID# 206473
🇵🇱Cracow, Malopolskie, Poland
McBk Sc /Id# 212575
🇵🇱Grodzisk Mazowiecki, Mazowieckie, Poland
Hospital Clinic /ID# 206575
🇪🇸Barcelona, Spain
NBR Polska /ID# 206476
🇵🇱Warsaw, Mazowieckie, Poland
Hospital Unversitario Marques de Valdecilla /ID# 202133
🇪🇸Santander, Cantabria, Spain
Revmatolog s.r.o. /ID# 202610
🇨🇿Jihlava 1, Jihlava, Czechia
Hospital Santa Creu i Sant Pau /ID# 206535
🇪🇸Barcelona, Spain
Vital Medical Center Orvosi-es Fogaszati Kozpont /ID# 202437
🇭🇺Veszprem, Hungary
Revita Reumatologiai Rendelo /ID# 202438
🇭🇺Budapest, Hungary
CRU Hungary Egeszsegugyi és Szolgaltato Kft. /ID# 202439
🇭🇺Miskolc, Borsod-Abauj-Zemplen, Hungary
Hospital Universitario Basurto /ID# 206462
🇪🇸Bilbao, Spain
University of Oxford /ID# 201974
🇬🇧Oxford, United Kingdom
Hospital Universitario y Politecnico La Fe /ID# 202139
🇪🇸Valencia, Spain
Hospital Clinico Universitario San Carlos /ID# 202135
🇪🇸Madrid, Spain
CMED Rehabilitacios es Diagnosztikai Kozpont /ID# 205804
🇭🇺Szekesfehervar, Hungary
Revmatologicky ustav Praha /ID# 202142
🇨🇿Prague 2, Praha 2, Czechia
CCR Czech a.s /ID# 202144
🇨🇿Pardubice, Czechia
AZ Arthritis and Rheum Researc /ID# 167448
🇺🇸Phoenix, Arizona, United States
Rheumatology Center of San Diego /ID# 170690
🇺🇸San Diego, California, United States
Lakes Research, LLC /ID# 170660
🇺🇸Miami, Florida, United States
Kendall South Medical Center, Inc. /ID# 206857
🇺🇸Miami, Florida, United States
Rheumatology Clinic of Houston /ID# 203689
🇺🇸Houston, Texas, United States
EmergeOrtho, P.A. /ID# 209154
🇺🇸Durham, North Carolina, United States
Health Research of Oklahoma /ID# 167370
🇺🇸Oklahoma City, Oklahoma, United States
Nashville Arthritis and Rheumatology /ID# 206699
🇺🇸Nashville, Tennessee, United States
Accurate Clinical Management /ID# 200481
🇺🇸San Antonio, Texas, United States
Rheumatic Disease Clin Res Ctr /ID# 167474
🇺🇸Houston, Texas, United States
Accurate Clinical Research /ID# 207059
🇺🇸Houston, Texas, United States
Metroplex Clinical Research /ID# 167458
🇺🇸Dallas, Texas, United States
Revmatologie MUDr. Klara Sirova /ID# 205185
🇨🇿Ostrava, Czechia
AZ Arthritis & Rheum Research /ID# 167446
🇺🇸Mesa, Arizona, United States
Rheum Assoc of North Alabama /ID# 167382
🇺🇸Huntsville, Alabama, United States
SunValley Arthritis Center, Lt /ID# 213073
🇺🇸Peoria, Arizona, United States
Valerius Medical Group /ID# 168123
🇺🇸Los Alamitos, California, United States
Purushotham, Akther & Roshan K /ID# 168121
🇺🇸La Mesa, California, United States
Inland Rheum Clin Trials Inc. /ID# 167459
🇺🇸Upland, California, United States
Iraj Sabahi Research, Inc /ID# 201923
🇺🇸Turlock, California, United States
Sierra Rheumatology /ID# 167976
🇺🇸Roseville, California, United States
Clinical Res of West FL, Inc. /ID# 167462
🇺🇸Clearwater, Florida, United States
Omega Research Maitland, LLC /ID# 167376
🇺🇸DeBary, Florida, United States
Rheumatology Consultants of De /ID# 208238
🇺🇸Lewes, Delaware, United States
Medvin Clinical Research /ID# 205731
🇺🇸Whittier, California, United States
Bay Area Arthritis and Osteo /ID# 208111
🇺🇸Brandon, Florida, United States
Riverside Clinical Research /ID# 167982
🇺🇸Edgewater, Florida, United States
Medallion Clinical Research Institute, LLC /ID# 201710
🇺🇸Naples, Florida, United States
Millennium Research /ID# 167453
🇺🇸Ormond Beach, Florida, United States
BayCare Medical Group /ID# 170860
🇺🇸Saint Petersburg, Florida, United States
Integral Rheumatology & Immunology Specialists /ID# 206724
🇺🇸Plantation, Florida, United States
International Medical Research - Ormond /ID# 170864
🇺🇸Ormond Beach, Florida, United States
Arthritis Center, Inc. /ID# 170695
🇺🇸Palm Harbor, Florida, United States
St. Anthony Comprehensive Rese /ID# 170668
🇺🇸Saint Petersburg, Florida, United States
Florida Medical Clinic /ID# 206279
🇺🇸Zephyrhills, Florida, United States
Deerbrook Medical Associates /ID# 207098
🇺🇸Vernon Hills, Illinois, United States
PRN of Kansas /ID# 167985
🇺🇸Wichita, Kansas, United States
Advanced Clinical Care /ID# 167367
🇺🇸Worcester, Massachusetts, United States
The Arthritis & Diabetes Clinic, Inc. /ID# 170682
🇺🇸Monroe, Louisiana, United States
Mansfield Health Center /ID# 167372
🇺🇸Mansfield, Massachusetts, United States
Beals Instititute /ID# 170658
🇺🇸Lansing, Michigan, United States
Arthritis Associates /ID# 209075
🇺🇸Hattiesburg, Mississippi, United States
Dhmc /Id# 167476
🇺🇸Lebanon, New Hampshire, United States
Arthritis and Osteo Assoc /ID# 167443
🇺🇸Las Cruces, New Mexico, United States
Physician Research Collaboration, LLC /ID# 200480
🇺🇸Lincoln, Nebraska, United States
North Mississippi Med Clinics /ID# 167377
🇺🇸Tupelo, Mississippi, United States
Cape Fear Arthritis Care /ID# 167413
🇺🇸Leland, North Carolina, United States
STAT Research, Inc. /ID# 200485
🇺🇸Vandalia, Ohio, United States
West Tennessee Research Inst /ID# 167366
🇺🇸Jackson, Tennessee, United States
Clinical Research Ctr Reading /ID# 170708
🇺🇸Wyomissing, Pennsylvania, United States
Arth and Osteo Clin Brazo Valley /ID# 209401
🇺🇸College Station, Texas, United States
Rheumatology and Pulmonary cli /ID# 170863
🇺🇸Beckley, West Virginia, United States
Arthritis & Osteoporosis Clinic /ID# 167407
🇺🇸Waco, Texas, United States
Sun Research Institute /ID# 170667
🇺🇸San Antonio, Texas, United States
Trinity Universal Research Association /ID# 209253
🇺🇸Plano, Texas, United States
CUB Hospital Erasme /ID# 201965
🇧🇪Brussels, Bruxelles-Capitale, Belgium
UZ Ghent /ID# 201757
🇧🇪Ghent, Oost-Vlaanderen, Belgium
Aurora Rheumatology and Immunotherapy Center /ID# 167385
🇺🇸Franklin, Wisconsin, United States
Dr. Latha Naik /ID# 212972
🇨🇦Saskatoon, Saskatchewan, Canada
Szabolcs-Szatmar-Bereg Megyei Korhazak & Egyetemi Oktatokorhaz /ID# 202441
🇭🇺Nyíregyháza, Szabolcs-Szatmar-Bereg, Hungary
GCM Medical Group, PSC /ID# 167983
🇵🇷San Juan, Puerto Rico
Hospital Regional de Malaga /ID# 202137
🇪🇸Málaga, Malaga, Spain
Reumatika - Centrum Reumatologii NZOZ /ID# 206472
🇵🇱Warsaw, Poland
Hospital Universitario A Coruña - CHUAC /ID# 202140
🇪🇸A Coruña, A Coruna, Spain
Warrington and Halton Teaching Hosp NHS Foundation Trust /ID# 206002
🇬🇧Warrington, United Kingdom
Hospital Universitario Virgen de las Nieves /ID# 209705
🇪🇸Granada, Spain
The Newcastle Upon Tyne Hospitals NHS Foundation Trust /ID# 201976
🇬🇧Newcastle Upon Tyne, United Kingdom
HMD Research LLC /ID# 208381
🇺🇸Orlando, Florida, United States
ForCare Clinical Research /ID# 206280
🇺🇸Tampa, Florida, United States
Cliniques Universitaires Saint Luc /ID# 201756
🇧🇪Woluwe-Saint-Lambert, Bruxelles-Capitale, Belgium
Rheum Assoc of Central FL /ID# 170858
🇺🇸Orlando, Florida, United States
Clinical Research of West Florida, Inc /ID# 169099
🇺🇸Tampa, Florida, United States
Rheumatology Research Assoc /ID# 207299
🇨🇦Edmonton, Alberta, Canada
Arthritis Northwest, PLLC /ID# 200479
🇺🇸Spokane, Washington, United States