The effects of propofol on the cardiac conduction system and the cardiac autonomic nervous system
Not Applicable
- Conditions
- Pediatric patients undergoing an electrophysiologic study and the radiofrequency catheter ablation
- Registration Number
- JPRN-UMIN000016448
- Lead Sponsor
- Deparment of Anesthesiology Kinki University Faculty of Medicine
- Brief Summary
Results and discussion Propofol significantly suppressed intrinsic cardiac HV conduction, but did not affect the SNRT, SACT or the AH interval. As HV blocks, which occur below the His bundle, are often life-threatening, the HV conduction delay may be a cause of severe AV blocks induced by propofol. Propofol directly suppressed parasympathetic nerve activity, and sympathetic nerve activity was also suppressed.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 23
Inclusion Criteria
Not provided
Exclusion Criteria
Patients with allergy to propofol and its solvents Patients with severe heart diseases Patients with liver dysfunction Patients with renal dysfunction
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method sinus node recovery time sinoatrial conduction time atrial-His intervals His-ventricular intervals heart rate valiability analysis
- Secondary Outcome Measures
Name Time Method