Dual Perfusion Imaging for Characterizing Vascular Architecture of Brain Lesions

Not Applicable

Recruiting

• Conditions: Brain Metastases; Brain Tumor
• Interventions: Diagnostic Test: Dynamic susceptibility contrast magnetic resonance imaging (DSC MRI)

• Registration Number: NCT05358340
• Lead Sponsor: University Health Network, Toronto

Brief Summary

The objectives of the study are (1) to evaluate the feasibility of using a combined spin- and gradient- echo (SAGE) sequence in dynamic susceptibility contrast magnetic resonance imaging (DSC MRI) and (2) to determine quantitative estimates of vessel density and size to differentiate between areas of radiation necrosis and tumor recurrence.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-09-24
• Study First Submitted: 2022-04-26
• Study First Submitted QC: 2022-05-02
• Study First Posted: 2022-05-03
• Status Verified: 2023-05
• Last Update Submitted: 2023-05-07
• Last Update Posted: 2023-05-09
• Primary Completion: 2024-08
• Study Completion: 2024-08

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Diagnosed with a brain metastasis or primary brain tumour and who will undergo MRI with contrast.

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Exclusion Criteria

• Subject or subject's legally authorized representative is unable or unwilling to consent to the study.
• Subject with documented contrast medium injection contraindication due to severe kidney disease or allergy.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Diagnostic (DSC MRI)	Dynamic susceptibility contrast magnetic resonance imaging (DSC MRI)	-

Primary Outcome Measures

Name	Time	Method
Measurement of perfusion parameter: cerebral blood volume (CBV)	Baseline to end of study (up to 2 years)	Measurements of cerebral blood volume (CBV) will be calculated.
Measurement of perfusion parameter: vessel size index (VSI)	Baseline to end of study (up to 2 years)	Measurements of vessel size index (VSI) will be calculated.

Trial Locations

Locations (1)

University Health Network; 🇨🇦 Toronto, Ontario, Canada