Modeling the Effect of EtCO2 on Cerebral Oxygenation

Not Applicable

Completed

• Conditions: Shoulder Surgery
• Interventions: Other: EtCO2

• Registration Number: NCT02284763
• Lead Sponsor: Severance Hospital

Brief Summary

The aim of this study was to investigate the relationship between the end-tidal carbon dioxide (EtCO2) and cerebral oxygen saturation (rSO2) and to identify the covariates in the pharmacodynamic relationship between EtCO2 and rSO2.

Detailed Description

Even though mild hypercapnia in the beach chair position (BCP) under general anesthesia was effective in reducing cerebral desaturation, there is no comprehensive data with regard to the dose-effect relationship of EtCO2 on rSO2 in the BCP under general anesthesia. Pharmacodynamic modeling can be useful in describing this relationship in which concurrent mean arterial pressure changes and disease state can be considered as covariates. Therefore, we investigated the relationship between the EtCO2 and rSO2 and identified the covariates in the pharmacodynamic relationship between EtCO2 and rSO2.

Study Timeline

• Study Start: 2014-10
• Study First Submitted: 2014-10-20
• Study First Submitted QC: 2014-11-03
• Study First Posted: 2014-11-06
• Primary Completion: 2015-01
• Study Completion: 2015-01
• Status Verified: 2015-02
• Last Update Submitted: 2015-02-10
• Last Update Posted: 2015-02-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 55

Inclusion Criteria

• Age ≥19 years who were scheduled to elective arthroscopic shoulder surgery in BCP under general anesthesia

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Exclusion Criteria

• Previous cerebrovascular disease, orthostatic hypotension, and the American Society of Anesthesiologists physical status IV or V

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Change of EtCO2	EtCO2	Changes of rSO2 after adjustment of EtCO2 between 27-45 mmHg

Primary Outcome Measures

Name	Time	Method
The parameters of indirect response model	60 min	fractional turnover rate (kout), baseline rSO2, baseline EtCO2, linear slope governing the relation between EtCO2 and rSO2
The factors that influence the model parameters	60 min	mean blood pressure, end-tidal desflurane concentration, age, sex, hypertention, diabetes mellitus, weight

Trial Locations

Locations (1)

Department of Anesthesiology and Pain Medicine and Anesthesia and Pain Research Institute, Yonsei University College of Medicine; 🇰🇷 Seoul, Korea, Republic of