Microbiology, Antimicrobial Resistance and Outcomes of Neonatal Sepsis in Chinese Neonatal Intensive Care Units
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 1,200
- 主要终点
- Overall mortality
研究概览
简要总结
Neonatal sepsis remains one of the most important cause of mortality and morbidities in China. This study will establish a prospective registral cohort of all infants with culture-proven neonatal sepsis in Chinese NICUs participating in the Chinese Neonatal Network (CHNN). The microbiology, antimicrobial resistance patterns and neonatal outcomes will be described in detail for this cohort.
详细描述
All infants with culture-proven sepsis in NICUs of CHNN will be enrolled in the study. Detailed data on microbiology, resistance pattern, neonatal mortality and morbidities will be collected and described. Risk factors for multi-resistant bacteria infections and for sepsis-related mortality will be identified.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 1 Hour 至 1 Month（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Admitted to CHNN NICUs from 2022.1.1 to 2023.12.31
- •Diagnosed with culture-proven sepsis
排除标准
- 未提供
结局指标
主要结局
Overall mortality
时间窗: About 3 months from admission to discharge or death
Incidence of death during the study period
次要结局
- Incidence of septic shock(About 3 months from admission to discharge or death)
- Incidence of multiorgan dysfunction(About 3 months from admission to discharge or death)
- Sepsis-related mortality (within 7 days of sepsis)(About 3 months from admission to discharge or death)
- Incidence of respiratory failure(About 3 months from admission to discharge or death)
- Incidence of disseminated intravascular coagulation (DIC)(About 3 months from admission to discharge or death)
- Incidence of necrotizing enterocolitis(About 3 months from admission to discharge or death)
- Incidence of meningitis(About 3 months from admission to discharge or death)
- Length of antibiotic treatment(About 3 months from admission to discharge or death)
- Type and quantity of transfusion(About 3 months from admission to discharge or death)
- Incidence of renal failure(About 3 months from admission to discharge or death)
- Incidence of brain injury(About 3 months from admission to discharge or death)
- Length of hospital stay(About 3 months from admission to discharge or death)