To evaluate Gut Brain Axis on cerebral Palsy childre

Not Applicable

Conditions: Health Condition 1: Q663- Other congenital varus deformitiesof feet

Recruitment & Eligibility

Inclusion Criteria

1.Age 5-15 years.

2.All type of cerebral palsy Spastic CP or 3.Dyskinetic CP or Ataxic CP or Mixed CP with 4.Hemiplegia and Diplegia.

5.Intelligence quotient >50 (Binet Kamat test/ MalinÃ¢â?¬•s Intelligence scale for children).

6.Modified Ashworth scoring 1-3 for affected limb .

7.Can sit independently or with support (GMFCS stage: 1-4 and Manual ability classification system stage:1-3) .

7.Preserved vision and hearing (with or without correction).

8.Ability to follow instructions and complete testing or Task.

9.No formal cognitive assessment was performed in past 6 months.

Exclusion Criteria

1.Uncontrolled epilepsy as defined by seizure 2.frequency > 1/month for preceding 3 months.

3.Ã?Â Severe concurrent illness of disease not 4.associated with CP or unstable medical conditions like pneumonia

5.Genetic or syndromic associations.

6.Children diagnosed with autistic spectrum disorders.

7.Modified Ashworth scale score >3 at shoulder/elbow/wrist.

8.Contractures of affected limb.

9.Severe movement disorder like dystonia, choreo-athetosis or ballismus interfering with purposeful limb movement.

10.Any congenital brain malformation detected on conventional MRI brain.

11.Any Malignancy/Cyst formation in the brain CT Scan or MRI Scan.

12.Recent orthopaedic surgery/ cast/splint in affected limb or any metallic implant.

13.Those receiving tone modifying agents.

On proton pump inhibitors 2 weeks before sample collection.

Primary Outcome Measures

Name	Time	Method
1.To investigate the alterations in gut motility, cognitive functions and cortical excitability in Cerebral Palsy Children. <br/ ><br>2.To correlate the impairment in gut motility, Autonomic Functions with severity of motor and cognitive deficits in CP. <br/ ><br>3.To compare the impairment of gut Ã¢â?¬â??brain axis among All CP Patients. <br/ ><br>Timepoint: just before the intervention and after the intervention

Secondary Outcome Measures

Name	Time	Method
1.To investigate the effect of probiotic on Gut motility ,motor ,cognitive deficits and cortical excitability in CP children. <br/ ><br> <br/ ><br>2.To assess metabolomic profiling of CP children by using LC MSMS. <br/ ><br> <br/ ><br>Timepoint: 1.To investigate the effect of probiotic on Gut motility ,motor ,cognitive deficits and cortical excitability in CP children. <br/ ><br> <br/ ><br>2.To assess metabolomic profiling of CP children by using LC MSMS. <br/ ><br> <br/ ><br>;1.To investigate the effect of probiotic on Gut motility ,motor ,cognitive deficits and cortical excitability in CP children. <br/ ><br> <br/ ><br>2.To assess metabolomic profiling of CP children by using LC MSMS. <br/ ><br> <br/ ><br>Timepoint: 1.To investigate the effect of probiotic on Gut motility ,motor ,cognitive deficits and cortical excitability in CP children. <br/ ><br> <br/ ><br>2.To assess metabolomic profiling of CP children by using LC MSMS. <br/ ><br> <br/ ><br>