New Markers for Treatment Response to Radiotherapy in Prostate Cancer
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- Bio-repository
研究概览
简要总结
The actual follow-up of patients undergoing definite radiotherapy for prostate cancer includes regular measurements of prostate specific antigen (PSA). Successful radiotherapy is critically dependent on local control of cancer; however, PSA takes 2-3 years to reach a nadir after therapy. We aim at collecting blood/urine after prostate massage before, and after radiotherapy in order to define new markers predicting local control earlier and more precisely than PSA.
详细描述
Patients will be closely followed for 5 years (weeks 0, 2, 4, 6, and months 2, 3, 6, 9, 12, 18, 24, and then yearly). Each assessment includes PSA measurement, urine collection after prostatic massage, and blood collection.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •All patients undergoing radiotherapy of biopsy confirmed clinically localised adenocarcinoma of the prostate
排除标准
- •patients with inflammatory processes of the rectum
- •patients with no rectum due to previous surgery
结局指标
主要结局
Bio-repository
时间窗: first assessment using predifined markers after recruitment of 15 patients followed for 1 year
次要结局
未报告次要终点
研究者
Cyrill Rentsch
MD-PhD
University of Basel