Comparative evaluation of ropivaciane with or without dexmedetomidine in ultrasound guided transversus abdominis plane (TAP) block for postoperative analgesia after laparoscopic cholecystectectomy
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- To evaluate the relative efficacy of ropivacaine with or without dexmedetomidine in ultrasound guided transversus abdominis plane (TAP) block for postoperative analgesia after laparoscopic cholecystectomy
研究概览
简要总结
Ultrasound guided Transversusabdominis plane (TAP) block is a regional analgesic technique that blocks abdominal neural afferents by introducing local anesthetic into the neurofascial plane between the internal oblique and the transversus abdominis muscles thereby reducing the postoperative pain of abdominal surgeries.Various local anesthetic agents including ropivacaine an S- enantiomer of bupivacaine have been used to provide effective and adequate postoperative analgesia in TAP block. Dexmedetomidine, the pharmacologically active d- isomer of medetomidine is a highly specific and selective α2adrenoreceptor agonist having both central as well as peripheral actions. xml:namespace prefix = o ns = "urn:schemas-microsoft-com:office:office" /
The present study is aimed at comparative evaluation and relative efficacy of ropivacaine(0.375%) and ropivacaine(0.375%) with dexmedetomidine(1mcg/kg) in ultrasound guided TAP block for post operative analgesia in laparoscopic cholecystectomy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant, Investigator and Outcome Assessor Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •â€¢ASA physical status I-II •Age 18-65 yrs •Body weight 50-75 kg of either sex BODY MASS INDEX ( > 18.
排除标准
- •â€¢History of relevant drug allergy •Age < 18yrs or >65yrs •History of psychiatric illness , substance abuse ,or medical therapies resulting in tolerance to opioids •Acute cholecystitis or pancreatitis •Severe cardiovascular , respiratory , metabolic, or neurological disease •Surgery requiring postoperative intraabdominal drainage •Pregnancy.
结局指标
主要结局
To evaluate the relative efficacy of ropivacaine with or without dexmedetomidine in ultrasound guided transversus abdominis plane (TAP) block for postoperative analgesia after laparoscopic cholecystectomy
时间窗: 10 min, 30 min, 1 hr, 4hr, 8hr, 12 hr and 24 hrs in the post operative period
次要结局
- To calculate the total dose of rescue analgesic over 24 hours in both the groups, and to(evaluate postoperative nausea and vomiting and to calculate the dose of antiemetic over)