Anastomotic Leakage After Anterior Resection of Rectal Cancer
- Conditions
- Rectal Cancer
- Registration Number
- NCT03281070
- Lead Sponsor
- Beijing Friendship Hospital
- Brief Summary
Anastomotic leakage (AL) is one of the most-feared postoperative complications after anterior resection of rectal cancer. This complication compromises both short term and long term outcome of patients. The incidence of AL after anterior resection was approximately 6-11%. Although several risk factors for AL such as male sex, smoking, tumor location, longer operative time, intraoperative blood loss had been reported in previous studies, the incidence of AL did not meet a significant decrease. So far there is no multi-site observational study on incidence and risk factors of AL after anterior resection in China, therefore this study aims to work on this issue and provide evidence for clinical practice.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 3000
- adenocarcinoma of the rectum by biopsy
- single lesion
- anterior resection was performed
- anastomosis using circular stapler
- history of colorectal cancer surgery
- emergency surgery because of bowel obstruction, bleeding or perforation
- colo-anal anastomosis
- subtotal colectomy
- total colectomy
- abdominal perineal resection
- Hartmann procedure
- pull out anastomosis
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Anastomotic leakage 14 days after surgery Anastomotic leakage is defined as a defect of the intestinal wall integrity at the colorectal anastomotic site leading to a communication between the intra- and extraluminal compartments.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Beijing Friendship Hospital
🇨🇳Beijing, China