The Incidence and Risk Factors of Anastomotic Leakage After Anterior Resection of Rectal Cancer: a Multi-site Observational Study
试验速览
- 阶段
- 不适用
- 入组人数
- 3,000
- 试验地点
- 1
- 主要终点
- Anastomotic leakage
研究概览
简要总结
Anastomotic leakage (AL) is one of the most-feared postoperative complications after anterior resection of rectal cancer. This complication compromises both short term and long term outcome of patients. The incidence of AL after anterior resection was approximately 6-11%. Although several risk factors for AL such as male sex, smoking, tumor location, longer operative time, intraoperative blood loss had been reported in previous studies, the incidence of AL did not meet a significant decrease. So far there is no multi-site observational study on incidence and risk factors of AL after anterior resection in China, therefore this study aims to work on this issue and provide evidence for clinical practice.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •adenocarcinoma of the rectum by biopsy
- •single lesion
- •anterior resection was performed
- •anastomosis using circular stapler
排除标准
- •history of colorectal cancer surgery
- •emergency surgery because of bowel obstruction, bleeding or perforation
- •colo-anal anastomosis
- •subtotal colectomy
- •total colectomy
- •abdominal perineal resection
- •Hartmann procedure
- •pull out anastomosis
结局指标
主要结局
Anastomotic leakage
时间窗: 14 days after surgery
Anastomotic leakage is defined as a defect of the intestinal wall integrity at the colorectal anastomotic site leading to a communication between the intra- and extraluminal compartments.
次要结局
未报告次要终点
研究者
Zhongtao Zhang
Department of General Surgery
Beijing Friendship Hospital