Pulmonary Hypertension Biorepository and Registry

Recruiting

• Conditions: Pulmonary Hypertension, Primary; Pulmonary Hypertension, Primary, 3; Pulmonary Hypertension; Chronic Thromboembolic Pulmonary Hypertension; Pulmonary Arterial Hypertension; Pulmonary Hypertension, Primary, 4; Pulmonary Hypertension, Primary, 2; Pulmonary Hypertension Due to Left Heart Disease; Pulmonary Hypertension Due to Lung Diseases and Hypoxia

• Registration Number: NCT04808596
• Lead Sponsor: University of Kansas Medical Center

Brief Summary

Establish a pulmonary hypertension registry and biorepository to lead towards a further understanding of the disease.

Detailed Description

The aim of this project will be to establish a broad and wide-ranging registry and biorepository of blood samples from patients with pulmonary hypertension, including all WHO groups I-V to be used for future research in these areas. This will be both a retrospective and prospective project. The registry and biorepository will be utilized to study and grow our knowledge of the cellular mechanisms and mediators of the disease and, in turn, contribute to advancements in treatment.

Study Timeline

• Study Start: 2020-08-10
• Study First Submitted: 2021-03-17
• Study First Submitted QC: 2021-03-17
• Study First Posted: 2021-03-22
• Status Verified: 2024-08
• Last Update Submitted: 2024-08-19
• Last Update Posted: 2024-08-21
• Primary Completion: 2026-12-31
• Study Completion: 2027-07-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

1. The participant is a patient at TUKHS or has agreed to participate in a study approved by the KUMC Human Research Protection Program (HRPP)
2. The participant has a diagnosis of pulmonary hypertension confirmed by right heart catheterization
3. Patient is ≥ 18 years of age or older

Exclusion Criteria

1. Participant declines to participate (living patients only)
2. Participant is unable to provide informed consent (living patients only)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Establish a Biorepository	From Enrollment to 6 Months	Establish a collection of biospecimens from patients with pulmonary hypertension.
Collaborate	From Enrollment to 24 Months	Provide biospecimens to researchers investigating pulmonary hypertension. Separate IRB approval will be needed for these studies.
Biospecimens Collection	From Enrollment to 12 Months	Correlate biospecimens to longitudinally collected individual patient data.
Collect Clinical Data	From Enrollment to 6 Months	Collect clinically obtained data from current and deceased patients with pulmonary hypertension to support research.

Trial Locations

Locations (1)

University of Kansas Medical Center; 🇺🇸 Kansas City, Kansas, United States