Use of Volatile Anesthetics for Long-Term Sedation In Critically Ill Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- atmospheric volatile concentration
研究概览
简要总结
Heavy sedation or sleep is a common problem within the intensive care unit (ICU) using our standard intravenous medications. This commonly leads to confusion, low blood pressure, slow wake up and removal of the artificial breathing tube (extubation), which prolongs ICU stay. Using inhaled volatile anesthetic agents are likely to improve these patient outcomes. This unique project is the first North American study looking at using volatiles for patients who need longer-term ICU sedation. This project has excellent potential at lowering these complications and improving quality of care, which will lower patient ICU stay and healthcare costs.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •adult ICU patients expected to be ventilated > 48 hours
排除标准
- •age < 18 years
- •history of malignant hyperthermia
- •propofol infusion syndrome
- •evidence of raised intracranial pressure
- •6-month mortality risk from pre-existing condition > 50%
- •lack of commitment to maximal treatment
- •NebulizedFlolan
- •tidal volume <350ml
- •patients on one lung ventilation
研究组 & 干预措施
intravenous propofol/midazolam
Sedation using intravenous propofol/midazolam, sedation will be titrated to a Riker Agitation Sedation Score
干预措施: Propofol/midazolam (Drug)
isoflurane
Sedation using inhaled isoflurane, sedation will be titrated to a Riker Agitation Sedation Score
干预措施: Isoflurane (Drug)
结局指标
主要结局
atmospheric volatile concentration
时间窗: daily
Daily assessment of atmospheric volatile levels will be measured using photometric multigas infrared analyzer
Sedation
时间窗: daily
adherence to the volatile sedation, sedation will be guided by explicit protocols targeting a Sedation-Agitation Score (SAS) of 3-4
Feasibility
时间窗: 2 years
assess rate of patient recruitment and barriers to recruitment
Education Tool
时间窗: 2 years
multidisciplinary feedback regarding teaching package, protocol, quality of sedation
serum fluoride levels
时间窗: every 2 days
Measurements will be taken 24 hours post sedation and every 2 days until while on sedation followed by 2 further samples after discontinuation of sedation.
次要结局
未报告次要终点