Study of the Cutaneous Expression of Prostaglandin F2-alpha (PGF2α) in Vitiligo Patients: a Case-control Study.
试验速览
- 阶段
- 不适用
- 入组人数
- 60
- 主要终点
- Measurement of tissue levels of PGF2α in vitiligo patients and compare them with healthy controls.
研究概览
简要总结
study the cutaneous expression of PGF2α in vitiligo patients and compare it with normal control subjects.
详细描述
Measurement of tissue levels of PGF2α in vitiligo patients and compare them with healthy controls.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients with non-segmental vitiligo.
- •Both sexes.
- •Age < 18 years old.
- •New cases or cases not receiving any medications for at least 3 months ago.
排除标准
- •Age: Patients < 18 years.
- •Segmental or universal vitiligo.
- •Pregnant and lactating females.
研究组 & 干预措施
vitiligo patients
Two skin biopsies (lesional and non-lesional) will be taken from every patient.
干预措施: Skin biopsy (Other)
healthy controls
A skin biopsy will be taken from each control subject.
干预措施: Skin biopsy (Other)
结局指标
主要结局
Measurement of tissue levels of PGF2α in vitiligo patients and compare them with healthy controls.
时间窗: 6 months
Measurement of tissue levels of PGF2α in vitiligo patients and compare them with healthy controls to study and verify the hypothesis of involvement of PGF2α in the pathogenesis of vitiligo.• Skin biopsy for assessment of tissue levels of the PGF2α will be taken from both lesional and non lesional skin of patients of vitiligo and from normal skin of healthy controls. All skin biopsies are from non-sun exposed sites.
次要结局
未报告次要终点
研究者
Maha Fathy Elmasry
principal investigator
Cairo University