Hyperoxic Oxidative Stress During Abdominal Surgery

Not Applicable

Completed

• Conditions: Response to Hyperoxia
• Interventions: Other: Fraction of inspired oxygen 40%; Other: Fraction of inspired oxygen 80%

• Registration Number: NCT01793454
• Lead Sponsor: Istanbul University

Brief Summary

Our aim is to compare the effects of 80% and 40% Fraction of inspired oxygen on oxidative stress, antioxidant response (in plasma and bronchoalveolar lavage), extubation quality, preanesthetic and postanesthetic expiration tidal volumes.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-02
• Study First Submitted: 2013-02-14
• Study First Submitted QC: 2013-02-14
• Study First Posted: 2013-02-15
• Primary Completion: 2013-05
• Study Completion: 2013-05
• Status Verified: 2015-04
• Last Update Submitted: 2015-04-08
• Last Update Posted: 2015-04-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Patients undergoing abdominal surgery, between 20-60 years old, with American Society of Anesthesiology score I or II

Exclusion Criteria

• Patients with Chronic Obstructive Pulmonary Disease, Diabetes Mellitus, muscle-bone diseases, inflammatory bowel diseases and patients with malnutrition.

Patients will be recruited through general surgery service of our hospital

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
40% oxygen	Fraction of inspired oxygen 40%	Patients in this group will be ventilated with fraction of inspired oxygen 40% during the surgery.
80% oxygen	Fraction of inspired oxygen 80%	Patients in this group will be ventilated with a fraction of inspired oxygen 80% during the surgery.

Primary Outcome Measures

Name	Time	Method
oxidant and antioxidant response	4 hours	As primary outcome, the effects of different inspired oxygen fractions on oxidative stress and anti-oxidant response in plasma and bronchoalveolar lavage after intubation and prior to extubation will be evaluated

Secondary Outcome Measures

Name	Time	Method
Hemodynamics	4 hours	The secondary outcome was evaluating the effects of different inspired oxygen fractions on hemodynamics.

Trial Locations

Locations (1)

Cerrahpasa Medical Faculty Anesthesiology and Reanimation Department; 🇹🇷 Istanbul, Fatih, Turkey