Acute Effects of Artificial Sweeteners and Sugar on the Brain Dynamics to Food Image Viewing. An Exploratory, Monocentric, Randomized Controlled Trial in Healthy Young Men
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 18
- 试验地点
- 2
- 主要终点
- Spatio-temporal brain dynamics
研究概览
简要总结
This study aims at investigating the acute influence of artificially sweetened beverages consumption (as compared with sugar-sweetened beverages and water consumption) on brain responses to the viewing of food images, on physiological responses (gut-derived hormones and lipid metabolites) and on the food intake behavior.
详细描述
This study is made on a randomized controlled crossover design including three conditions (water, sugar, artificial sweeteners). Measurements will be performed in fasting and fed conditions. The test-meal will comprise either an artificially or sugar-sweetened beverage or water (control). The spatio-temporal brain dynamics to the viewing of food pictures will be assessed by means of electroencephalography (EEG) recordings and electrical neuroimaging analyses. Venous blood and urine will be collected. Blood pressure, cardiac frequency and bio-impedance measurements will be performed. Food intake behavior will be assessed by means of questionnaires and a free-choice buffet. Each tested condition (water, sugar, artificial sweeteners) will be preceded by a run-in period during which the participants' diet will be controlled (2-day isoenergetic diet).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Caucasian
- •Right-handed
- •Weak to normal physical activity (< 3hours per week)
- •Normal-weight (19<BMI<25 kg/m2)
- •Regular consumption of sugar-sweetened beverages (>33cl per week)
排除标准
- •Consumption of artificially sweetened beverages exceeding 33cl per week
- •Cardiovascular, kidney, hepatic and/or psychological disorders
- •Blood pressure at rest > 140/90mmHg
- •Body weight < 50kg
- •Hemoglobin < 13.5g/dl
- •Ferritin < 50microg/l
- •Drug consumption
- •Alcohol consumption (>10g/day)
- •Any particular diet (e.g. vegetarianism), food allergy and/or intolerance
- •Body weight gain or loss of >3kg during the last 3 months
结局指标
主要结局
Spatio-temporal brain dynamics
时间窗: differences observed between 60 min before and 60 min after ingestion of a test meal
Spatio-temporal brain dynamics to the viewing of food will be assessed by means of electroencephalography recordings.
次要结局
- spontaneous food intake(240 min after ingestion of a test meal)
- Changes in concentration of blood triglyceride(-120 min before ingestion of a test meal, and 30, 60, 90, 150, and 210 min after ingestion of a test meal)
- Changes in concentration of blood Fibroblast Growth Factor (FGF)-21(-120 min before ingestion of a test meal, and 30, 60, 90, 150, and 210 min after ingestion of a test meal)
- Changes in concentration of blood insulin(-120 min before ingestion of a test meal, and 30, 60, 90, 150, and 210 min after ingestion of a test meal)
研究者
Luc Tappy, MD
Full professor
University of Lausanne