DRKS00030856招募中Unknown
Major Depression as a transient functional lesion model of motor control – longitudinal study - MoCo-D2
niklinik Köln, Klinik für Psychiatrie und Psychotheapie0 个研究点目标入组 40 人开始时间: 2023年8月21日最近更新:
适应症
试验速览
- 阶段
- Unknown
- 状态
- 招募中
- 发起方
- 入组人数
- 40
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- N/a: Single Arm Study
- 盲法
- Open (masking not used)
入排标准
- 年龄范围
- 18 Years 至 one（—）
- 性别
- All
入选标准
- •Age equal to or above 18 years
- •Capacity to provide informed consent
- •Written informed consent form by the participant
- •Depressive episode according to ICD-10. The diagnosis will be established by a senior psychiatrist and will be based on clinical examination with the application of the ICD-10 criteria.
- •Minimal symptoms of motor dysfunction observed on clinical examination and expressed by a Salpetrière Retardation Rating (in depression) Scale (SRRS) score of >1 on the items of motility or slowing of speech.
排除标准
- •Patients with depression according to ICD-10
- •Principal inclusion criteria:
- •Age equal to or above 18 years
- •Capacity to provide informed consent
- •Written informed consent form by the participant
- •Depressive episode according to ICD-10. The diagnosis will be established by a senior psychiatrist and will be based on clinical examination with the application of the ICD-10 criteria.
- •Minimal symptoms of motor dysfunction observed on clinical examination and expressed by a Salpetrière Retardation Rating (in depression) Scale (SRRS) score of >1 on the items of motility or slowing of speech.
- •Principal exclusion criteria:
- •MRI contraindication: cardiac pacemaker or neurostimulator implantation, metal implants (except teeth), agoraphobia, history of metalworking, injury with shrapnel or metal slivers, and major surgery
- •Acute suicidality (standardized assessment with the Columbia suicide severity rating scale, C-SSRS)
- •Bipolar disorder, schizophrenia, dementia
- •Substance use disorder (current or in the past 5 years)
- •Neurological diseases (e.g., Parkinson´s disease, multiple sclerosis, history of stroke)
- •Immune disorder (except Hashimoto-Thyreoditis)
- •Clinical signs of acute infection
- •Known dysfunction of the motor system independent of motor retardation related to depression
- •Constant treatment with antipsychotic medication, intake on the days of examination
- •Constant treatment with Benzodiazepines, intake on the days of examination
- •Constant tobacco consumption (>10 cigarettes/day)
- •Pregnant women and nursing mothers
研究者
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