The Relation Between Uric Acid Level and Endothelial Dysfunction in Patients With Polycystic Kidney Disease

Terminated

• Conditions: Polycystic Kidney, Autosomal Dominant

• Registration Number: NCT01589705
• Lead Sponsor: TC Erciyes University

Brief Summary

There are substantial data demonstrating increased endothelial dysfunction, inflammation and oxidative stress in patients with Autosomal dominant polycystic kidney disease (ADPKD), the association between serum uric acid level and endothelial dysfunction has not been elucidated yet in these patients. Therefore, in this study, the investigators aimed to examine the relationship between the uric acid level and the ED in normotensive ADPKD patients with preserved renal function.

Detailed Description

This is the first study to evaluate the relationship between uric acid and endothelial dysfunction in patients with early stage ADPKD

Study Timeline

• Study Start: 2012-01
• Primary Completion: 2012-04
• Study Completion: 2012-04
• Study First Submitted: 2012-04-30
• Study First Submitted QC: 2012-05-01
• Study First Posted: 2012-05-02
• Status Verified: 2012-07
• Last Update Submitted: 2012-07-29
• Last Update Posted: 2012-07-31

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

• ADPKD patients with normal renal function,
• Normotensive ADPKD patients

Exclusion Criteria

• Patients with impaired kidney function,
• Atherosclerotic disorders,
• Diagnosis of hypertension, gout, diabetes,
• Using of insulin, thiazide, allopurinol or uricosuric drugs

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Measurement of asymmetric dimethylarginine (ADMA) and flow mediated dilatation (FMD)	4 months	ADMA,FMD and uric acid measurements were performed to determine endothelial dysfunction in ADPKD patients

Trial Locations

Locations (1)

Erciyes University Medical School; 🇹🇷 Kayseri, Turkey