Endothelial Dysfunction in Patients With Polycystic Kidney Disease
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- Measurement of asymmetric dimethylarginine (ADMA) and flow mediated dilatation (FMD)
研究概览
简要总结
There are substantial data demonstrating increased endothelial dysfunction, inflammation and oxidative stress in patients with Autosomal dominant polycystic kidney disease (ADPKD), the association between serum uric acid level and endothelial dysfunction has not been elucidated yet in these patients. Therefore, in this study, the investigators aimed to examine the relationship between the uric acid level and the ED in normotensive ADPKD patients with preserved renal function.
详细描述
This is the first study to evaluate the relationship between uric acid and endothelial dysfunction in patients with early stage ADPKD
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 20 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ADPKD patients with normal renal function,
- •Normotensive ADPKD patients
排除标准
- •Patients with impaired kidney function,
- •Atherosclerotic disorders,
- •Diagnosis of hypertension, gout, diabetes,
- •Using of insulin, thiazide, allopurinol or uricosuric drugs
结局指标
主要结局
Measurement of asymmetric dimethylarginine (ADMA) and flow mediated dilatation (FMD)
时间窗: 4 months
ADMA,FMD and uric acid measurements were performed to determine endothelial dysfunction in ADPKD patients
次要结局
未报告次要终点
研究者
Ismail Kocyigit
TC Erciyes University Medical School
TC Erciyes University