Knee joint (in)stability in patients with knee osteoarthritis* - Stability in Osteoarthritis (STOA)

Vrije Universiteit Medisch Centrum0 个研究点目标入组 80 人开始时间: 待定最近更新: 2024年2月28日

适应症

试验速览

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•In order to be eligible to participate the study, a knee osteoarthitis (KOA) subject must meet all of the following criteria:
•- Unilateral or bilateral diagnosis of the KOA according to the American college of Rheumatology (ACR) criteria. ACR criteria are age over 50 years, morning stiffness less than 30 minutes, crepitus on active motion, bony tenderness or absence of palpable warmth of synovium.
•- Able to walk for 5 minutes without stopping.
•- A maximal score of 7 on the numeric scale (NRS) for pain intensity during the past two weeks.
•- Body mass index (BMI) between 20 and 35 kg/m2.;The KOA subjects will be assigned to the KOA-I group (group with unstable knees) based on the following criterion:
•- Have had the perception of an episode of buckling, shifting or giving way of the knee in the past 4 weeks based on questionnaire (KOS-ADLS).;The KOA subject will be assigned to the KOA-S group (group with stable knees) based on the following criterion:
•- Have had no perception of an episode of buckling, shifting or giving way of the knee in the past 3 months on questionnaire (KOS-ADLS).;Healthy controls will be age matched, gender matched and BMI matched with the total KOA group (i.e. similar mean ± standard deviation as total KOA group, except for gender which will be about the same ratio as the total KOA group (+- 3%)).

•Potential KOA subject meeting any of the following criteria will be excluded from participation in the study:
•- Diagnosed with hip osteoarthritis, rheumatoid arthritis or any other form of inflammatory arthritis (i.e., septic arthritis, crystal arthropathy)
•- Has a lower extremity joint replacement.
•- Has had a knee related injury last year.
•- Not signed an informed consent.;A potential control subject meeting any of the following criteria will be excluded from participation in the study:
•- Diagnosed with a musculoskeletal disease.
•- Has a lower extremity joint replacement.
•- Has had a knee related injury last five years.
•- Has knee-related problems.
•- Not signed an informed consent.

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