Adenosine’s effect on STunning resolution in Acute Myocardial Infarction

Västra Götalandsregionen, Sahlgrenska University Hospital0 个研究点目标入组 90 人开始时间: 2021年4月26日最近更新: 2024年7月15日

适应症

试验速览

暂无简介。

•1.Age = 18 years.
•2.A clinical diagnosis of anterior STEMI
•3.Symptom duration =6 hours
•4.Written informed consent obtained
•Angiographic inclusion criteria
•a.Culprit lesion in LAD, major branch of LAD, proximal or mid LCx or proximal or mid RCA
•b.TIMI flow =2 in the culprit vessel
•Echocardiographic inclusion criteria
•c.Detectable hypo- or akinesia corresponding to =5% of the left ventricle corresponding to culprit lesion, per bedside visual assessment.
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 45
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range 45

•1.Previous randomization in the study
•2.Any of the following contraindications for treatment with adenosine:
•a.Known pre-existing atrioventricular block grade =2 or sick sinus syndrome in patients without pacemaker.
•b.Known pre-existing elevation of intracranial pressure
•c.Treatment with dipyridamole within 24 hours of randomization
•d.Systolic blood pressure <80 mm Hg at screening
•3.Any concomitant condition resulting in a life expectancy of less than one month
•4.Previous myocardial infarction or other cardiac condition resulting in impaired regional or global systolic function without documented recovery of cardiac function
•5.Heart transplant or left ventricular assist device recipient
•6.Not suitable in the opinion of the investigator due to severe or terminal comorbidity with poor prognosis or characteristics that may interfere with adherence to the trial protocol
•7.Pregnancy or woman of childbearing potential who is not sterilized or using a medically accepted form of contraception

发起方

Västra Götalandsregionen, Sahlgrenska University Hospital