Pre-emptive US Guided Superior Hypogastric Plexus Block in Pelvic Cancer Surgeries : a Randomized Double-Blinded Study

Not Applicable

• Conditions: Analgesia
• Interventions: Procedure: Superior Hypogastric Plexus Block

• Registration Number: NCT04732234
• Lead Sponsor: National Cancer Institute, Egypt

Brief Summary

The superior hypogastric plexus (SHP) is a retroperitoneal structure with a predominance of afferent sympathetic nerve fibers. The perception of central pelvic pain is thought mainly to involve transmission through this plexus. Therefore, blocking or of SHP has been used to treat pelvic pain.

Detailed Description

Ultrasound guided superior hypogastric plexus block there is 2 equal groups:

Group S (SHPB group 18 patients) ultrasound guided SHPB is done after induction of balanced general anesthesia (fentanyl, propofol and rocuronium) using 20 ml Bupivacaine 0.5% before skin incision, Group C (Control group 18 patients) in which same technique will be done but using normal saline 0.9% instead of bupivacaine. Patients of both groups will receive patient controlled analgesia using morphine with continous background infusion of morphine 1.5 mg/h with adding granisterone 2mg/60 ml and ability to give bolus of 0.5 mg morphine on demand.

• Dosing and administration; Group S (SHPB group 18 ultrasound guided SHPB ) using 20 ml Bupivacaine 0.5% before skin incision.

Group C (Control group 18 patients) in which same technique will be done but using normal saline 0.9%

Study Timeline

• Study Start: 2020-12-01
• Study First Submitted: 2020-12-25
• Status Verified: 2021-01
• Study First Submitted QC: 2021-01-26
• Last Update Submitted: 2021-01-26
• Study First Posted: 2021-02-01
• Last Update Posted: 2021-02-01
• Primary Completion: 2021-05
• Study Completion: 2021-05

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• ASA II,III.
• Patients undergoing pelvic surgeries.

Exclusion Criteria

• Patients refusal,
• Coagulopathy,
• Infection.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
(Group B)	Superior Hypogastric Plexus Block	ultrasound guided superior hypogastric plexus block using 20 ml normal saline 0.9% instead of bupivacaine.
( Group A)	Superior Hypogastric Plexus Block	ultrasound guided superior hypogastric plexus block using 20 ml Bupivacaine 0.5% before skin incision.

Primary Outcome Measures

Name	Time	Method
morphine consumption	baseline till 24 hours postoperative	Total 24 hours morphine consumption in milligrams

Secondary Outcome Measures

Name	Time	Method
Visual analogue scale (VAS)	Visual analogue scale (VAS) at baseline till 24 hours postoperative	scale in which 0 is least pain and 10 is sever pain

Trial Locations

Locations (1)

Nataional Cancer Instituite; 🇪🇬 Cairo, Egypt