Spectroscopic Profiling of Extracellular Vesicles By Resonant Gold Nanostructures in the Infrared

Recruiting

• Conditions: Vesicle
• Interventions: Diagnostic Test: sierological test

• Registration Number: NCT06266195
• Lead Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Brief Summary

Extracellular vesicles, due to their ease of extraction and ability to represent the cells from which they originate, have high potential in the field of personalized medicine, especially in the identification of new early bio-markers of cancer, including hepatocellular carcinoma. Nevertheless, the development of high-throughput diagnostic methods in this area is still in its infancy, and the design of new integrated technological solutions is of great interest and topicality. The main hypothesis of this study is that the development of a novel technology integrating resonant gold nanostructures in the mid-infrared can significantly contribute to the development of new approaches for the diagnosis of hepatocellular carcinoma.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-03-15
• Status Verified: 2023-04
• Study First Submitted: 2023-07-21
• Primary Completion: 2023-12-31
• Study First Submitted QC: 2024-02-12
• Last Update Submitted: 2024-02-12
• Study First Posted: 2024-02-20
• Last Update Posted: 2024-02-20
• Study Completion: 2025-02-28

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 64

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
GRUPPO HCC	sierological test	32 pazienti uomini o donne, con diagnosi di neoplasia primitiva del fegato
GRUPPO CIRROSI	sierological test	32 soggetti uomini o donne, \>18 anni con diagnosi di cirrosi epatica di differente eziologiA

Primary Outcome Measures

Name	Time	Method
primary endpoint	12 months	To evaluate the change in extracellular vesicle concentration between the control group and oncology group. The concentration of vesicles per ml of blood will be measured by frequency shift of the plasmonic resonance peak of gold nanostructures following immuno-capture of vesicles.

Trial Locations

Locations (1)

FPGemelliIRCCS; 🇮🇹 Roma, Lazio, Italy