Does Flow Trigger Sensitivity Adjustment Is Translational Mechanisms For Therapeutically Alternatives In Ventilator-Induced Diaphragm Dysfunction Critically Ill Patients?
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 30
- 主要终点
- Blood Pressure mmHg
研究概览
简要总结
The study is a prospective experimental study on adult patients admitted to the Critical Care Department in Qasr Al-Ainy. This study is conducted prospectively to assess the efficiency of trigger sensitivity adjustment on patients with ventilator-induced diaphragmatic dysfunction (VIDD).
详细描述
The study is a prospective experimental study on adult patients admitted to the Critical Care Department in Qasr Al-Ainy. This study is conducted prospectively to assess the efficiency of trigger sensitivity adjustment on patients with ventilator-induced diaphragmatic dysfunction (VIDD).1. Flow Trigger: This type of trigger responds to the gas flow during inspiration. A flow trigger measures the rate of change of flow as the patient begins to inhale. When the flow reaches a certain threshold, the ventilator is triggered to deliver a breath.
- Laboratory investigations: Arterial blood gases (ABG):- (PH, PCO2, HCO3, and PO2) after the session.
- Ventilator Parameters:( a) Minute Ventilation, b) Tidal Volume, c) Rapid Shallow breathing index, d) Negative Inspiratory Force (NIF) will be measured pre and post-treatment
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
盲法说明
Our Study was performed on sixty patients with VIDD from both genders. All patients will be referred by a physician. All patients were randomly assigned into two groups equal in number
入排标准
- 年龄范围
- 20 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age (years)
- •Weight (kg)
- •Height (cm)
- •BMI (kg/m²)
- •Inclusion Criteria:
- •Patients who had undergone MV for 48 hours or more in a controlled mode.
- •Patients could not generate maximum inspiratory pressure of more than 15 mbar
- •Patients had diaphragmatic excursion less than 3 cm. (normal level from 3 to 5 cm.)(It can increase in a condition person to 7-8 cm).
- •Patients had a diaphragmatic thickness fraction of less than 30%
排除标准
- •Patients with comorbidities interfering and compromising weaning like cardiac arrhythmia, pericardial effusion, congestive heart failure, or unstable acute coronary syndrome.
- •Patients who had inadequate training performance of the inspiratory muscle such as those having myopathy or neuropathy.
- •Patients hemodynamically unstable.
- •Patients who had a major neurological deficit.
- •Sedated Patients.
研究组 & 干预措施
Study group
Group (A) (study group) will include 30 patients who practiced flow trigger sensitivity adjustment on mechanical ventilation for 1 week twice daily in addition to their plan of treatment.
干预措施: Practice flow trigger sensitivity adjustment on mechanical ventilation for 1 week twice daily in addition to their plan of treatment. (Device)
Controlled group
Group (B) (controlled group) will include 30 patients who received their routine plan of weaning of mechanical ventilator (controlled mode then spontaneous mode and finally spontaneous breathing trial).
干预措施: Practice flow trigger sensitivity adjustment on mechanical ventilation for 1 week twice daily in addition to their plan of treatment. (Device)
结局指标
主要结局
Blood Pressure mmHg
时间窗: one week
Blood Pressure mmHg
HCO3 mEQ/Liter
时间窗: one week
HCO3 mEQ/Liter
Arterial blood gases (ABG):-
时间窗: one week
PH
PCO2 mmHg
时间窗: one week
PCO2 mmHg
PSAO2 mmHg
时间窗: one week
PSAO2 mmHg
Vital signs
时间窗: one week
Heart Rate (HR) b/min
Respiratory rate RR/min
时间窗: one week
Respiratory rate RR/min
次要结局
- Tidal Volume L/breath(one week)
- Ventilator parameters(one week)
研究者
Ibrahim Abuzaid
Director, Head of Department of Physiotherapy for Cardiovascular/Respiratory and Geriatrics
South Valley University