EVALUATION OF CORNEAL EPITHELIAL THICKNESS MAPPING IN DIABETIC PATIENTS USING ANTERIOR SEGMENT OPTICAL COHERENCE TOMOGRAPHY AND ITS CORRELATION TO MACULAR THICKNESS
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 153
- 试验地点
- 1
- 主要终点
- corneal epithelial thickness
研究概览
简要总结
The corneal epithelium is the outermost layer that covers the front of the eye; it not only functions as a barrier that blocks the passage of foreign material, but also plays an important role in maintaining high optical quality. The stem cells in the basal layer of the limbal epithelium hold a physiological significance in the renewal and metabolism of corneal epithelium, particularly under stressful situations.
详细描述
The cornea in diabetic patients suffers from cellular dysfunction and dysfunctional repairal mechanisms, which include recurrent erosions, delayed wound healing, ulcers, and edema. In addition and undoubtedly related to epithelial dysfunction, alterations in epithelial basement membrane occur.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 40 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •The patients aged between 40- 60 years old of both genders.
- •The patients in (Group A) should be diabetics for more than 10 years and free from any other systemic diseases with diabetic macular edema (by OCT).
- •The patients in (Group B) should be diabetics for more than 10 years and free from any other systemic diseases without diabetic macular edema (by OCT).
- •The patients in (Group C) should be free of any systemic diseases and normal macular thickness (by OCT)
排除标准
- •Previous history of any intraocular surgery, intravitreal injection, laser or refractive surgery.
- •Ocular surface disorders (e.g. dry eye) or any corneal pathology.
- •Corneal scars or epithelial dystrophies.
- •Use of any topical medications.
- •Elevated IOP, pregnancy or lactation.
结局指标
主要结局
corneal epithelial thickness
时间窗: 2 years
corneal thickness in diabetics using OCT
次要结局
未报告次要终点
研究者
Hosny Ahmed Zein
DR. HOSNY AHMED ZEIN
Minia University