Immune respons after inactivated oral cholera vaccination (Dukoral) in kidneytransplant recipients. Mucosal immune response in ImmunoCompromised Host (MICH) - MICH

eids Universitair Medisch Centrum0 个研究点目标入组 70 人开始时间: 待定最近更新: 2024年5月6日

试验速览

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•- Age >= 18 years
•- Creatinin clearance >= 40 ml/min
•- Stable renal function for 1 year prior to inclusion
•- Stabe immunosuppressive medication for 3 months prior to inclusion, consisting of prednisone in combination with either a calcineurine inhibitor, mycophenolate mofetil or an mTOR inhibitor

•- A chronic disease which may influence the immune system, other than the renal transplant and accompanying immunosupressive medication
•- Chronic infection
•- Treatment for graft rejection in the year prior to inclusion
•- Prior vaccination with Dukoral or another oral cholera or ETEC vaccine.
•- Prior Vibrio cholerae infection
•- Travellers' diarrhea 6 months prior to inclusion
•- Known allergy to the vaccine or to one of the vaccine components
•- History of an anaphylactic reaction following vaccination
•- Treatment with plasma or blood products in the 3 months prior to inclusion
•- Pregnancy or breast feeding
•- Immunosuppressive medication other than prednisone, a calcineurine inhibitor, mycophenolate mofetil or an mTOR inhibitor

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