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Clinical Trials/NCT01263249
NCT01263249
Completed
Phase 4

Continuous Femoral Nerve Blocks: Effects of Catheter Tip Location Relative to the Femoral Nerve on Sensory and Motor Function

University of California, San Diego1 site in 1 country19 target enrollmentJanuary 2010
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ConditionsContinuous Femoral Nerve Blocks in Healthy Volunteers

Overview

Phase
Phase 4
Intervention
Not specified
Conditions
Continuous Femoral Nerve Blocks in Healthy Volunteers
Sponsor
University of California, San Diego
Enrollment
19
Locations
1
Primary Endpoint
Quadriceps femoris muscle strength
Status
Completed
Last Updated
14 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSitesSimilar Trials

Overview

Brief Summary

To determine if the way local anesthetic, or numbing medication, is delivered through a tiny tube next to the nerves that go to the thigh affects the strength and sensation in the thigh.

Detailed Description

Specific Aim: Research study to test the hypothesis that differing the location of the perineural catheter tip during a continuous femoral nerve block (anterior vs. posterior) impacts quadriceps muscle strength. These results will help define the optimal perineural catheter tip location relative to the femoral nerve used for continuous peripheral nerve blocks and help guide both clinical care and future research in this clinically-relevant area.

Registry
clinicaltrials.gov
Start Date
January 2010
End Date
June 2011
Last Updated
14 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Eligibility Criteria

Inclusion Criteria

  • •18 years of age or over
  • •Willing to have bilateral femoral perineural catheters placed with a subsequent ropivacaine infusion and motor/sensory testing for 6 hours, requiring an overnight stay in the UCSD GCRC/CTRI to allow dissipation of local anesthetic infusion effects by the following morning

Exclusion Criteria

  • •current daily analgesic use
  • •opioid use within the previous 4 weeks
  • •any neuro-muscular deficit of either femoral nerves and/or quadriceps muscles
  • •body mass index \> 30 kg/m2
  • •pregnancy
  • •incarceration

Outcomes

Primary Outcomes

Quadriceps femoris muscle strength

Time Frame: percentage of baseline muscle strength six hours after infusion initiation

The primary end point will be the quadriceps femoris maximum voluntary isometric contraction (MVIC) expressed as a percentage of the pre-ropivacaine MVIC: post / pre x 100; with the two sides of each subject compared with each other

Study Sites (1)

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