Mechanisms of Arm Recovery in Stroke Patients With Hand Paralysis
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- George Mason University
- Enrollment
- 10
- Locations
- 1
- Primary Endpoint
- Change in movement time
Study Overview
Brief Summary
This study examines the effect of non-invasive brain stimulation targeting different brain areas on movement of the affected arm post-stroke. Participants will receive stimulation to each of 3 different brain areas combined with a session of arm exercise.
Detailed Description
Small improvements in affected arm movement can be made with intensive physical practice. These improvements could potentially be enhanced by combining non-invasive brain stimulation with practice.
To develop such an intervention, it is necessary to understand which brain areas should be stimulated in which types of patients. It is probably more beneficial to target one side of the brain vs. the other, for example, depending on the characteristics of the stroke.
This study will examine the effect of stimulating one side of the brain vs. the other on the amount of improvement that occurs from physically practicing functional arm movements.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Treatment
- Masking
- Single (Outcomes Assessor)
Masking Description
The individual that conducts the tests of arm movement will be unaware of which brain area was stimulated.
Eligibility Criteria
- Ages
- 18 Years to 85 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •More than 6 months post-stroke
- •Loss of voluntary finger movement in the affected hand
- •Some voluntary movement of affected shoulder and/or elbow
Exclusion Criteria
- •Brainstem or cerebellar stroke
- •Severe cognitive or language deficits
- •Epilepsy or other seizure disorder
- •Central nervous system disease or disorder other than stroke
Arms & Interventions
Unaffected Hemisphere
Application of "Unaffected Transcranial Magnetic Stimulation" to unaffected hemisphere site prior to physical practice
Intervention: Unaffected Transcranial Magnetic Stimulation (Procedure)
Affected Hemisphere
Application of "Affected Transcranial Magnetic Stimulation" to affected hemisphere site prior to physical practice
Intervention: Affected Transcranial Magnetic Stimulation (Procedure)
Control Site
Application of "Control Transcranial Magnetic Stimulation" to control site prior to practice
Intervention: Control Transcranial Magnetic Stimulation (Procedure)
Outcomes
Primary Outcomes
Change in movement time
Time Frame: Baseline and 1 Day
Percentage change in time it takes to move the arm a standardized distance
Secondary Outcomes
- Change in maximum reaching distance(Baseline and 1 Day)
- Change in hand path kinematics(Baseline and 1 Day)