Prospective Single Center Cohort Study for Early Detection of Cardiac Dysfunction in Childhood Cancer Survivors
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Cardiac Dysfunction
- Sponsor
- University of Bern
- Enrollment
- 500
- Locations
- 6
- Primary Endpoint
- Prevalence of impaired exercise capacity
- Status
- Recruiting
- Last Updated
- 12 months ago
Overview
Brief Summary
This multicenter, prospective cohort study evaluates early cardiac dysfunction in adult survivors of childhood cancer. The hypothesis of this study is that cardiac dysfunction can be detected earlier when using speckle tracking echocardiography as novel echocardiographic technique compared to conventional echocardiography.
Detailed Description
Cardiovascular disease including cardiac dysfunction is the leading non-malignant cause of death in childhood cancer survivors. Early detection of cardiac dysfunction is important to identify those in need for medical intervention to improve outcome. This study invites adult childhood cancer survivors to a clinical appointment to the University Hospital Bern, Switzerland. A detailed, standardized cardiac assessment including conventional and novel echocardiographic techniques (speckle tracking) as well as cardiopulmonary exercise testing is performed. Cardiac dysfunction is evaluated in survivors who have had cardiotoxic cancer therapy with anthracyclines and/or chest radiation (high risk) and in survivors who have had chemotherapy other than anthracyclines (standard risk).
Investigators
Eligibility Criteria
Inclusion Criteria
- •Registered in the ChCR
- •Formerly treated at the Department of Pediatric Hematology/Oncology of one of five participating centers
- •Treated with any chemotherapy and/or chest radiation
- •Survived ≥ 5 years since most recent cancer diagnosis (primary cancer, relapse(s), secondary cancer) at time of examination
- •Diagnosed at age ≤ 20 years
- •≥ 18 years of age at time of study participation
- •Resident in Switzerland
- •Written informed consent
Exclusion Criteria
- •Study participants will be excluded if they do not meet the above mentioned inclusion criteria or refuse to participate in the study.
Outcomes
Primary Outcomes
Prevalence of impaired exercise capacity
Time Frame: Baseline
Cardiopulmonary exercise testing: peak oxygen consumption, percent-predicted carbon dioxide production
Treatment-related risk factors
Time Frame: Baseline
Dose of chest radiation (Gray)
Prevalence of cardiac dysfunction
Time Frame: Baseline and longitudinal follow-up where clinically indicated
Speckle tracking echocardiography: longitudinal (LS), circumferential (CS), and radial strain (RS)