Comparison of Effectiveness of Topical Retinoids Versus Liquid Nitrogen in Treatment of Plantar Warts(Viral Infection)

Phase 4

Recruiting

• Conditions: Viral Warts
• Interventions: Drug: Topical Adapalene Gel 0.1%; Procedure: Topical Liquid Nitrogen application

• Registration Number: NCT07016360
• Lead Sponsor: Khyber Teaching Hospital

Brief Summary

This is a comparative study between two treatment options for skin viral infection.

Detailed Description

This is a comparative study between two treatment for viral infection in epidermal layer of skin that proliferates slowly forming thick, growths. This study will compare and evaluate the differences in efficacy between topical liquid nitrogen and topical retinoids.

Study Timeline

• Study First Submitted: 2025-05-21
• Status Verified: 2025-06
• Study First Submitted QC: 2025-06-03
• Last Update Submitted: 2025-06-03
• Study First Posted: 2025-06-11
• Last Update Posted: 2025-06-11
• Study Start: 2025-06-15
• Primary Completion: 2025-12-31
• Study Completion: 2025-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 98

Inclusion Criteria

Patients age limit 18-60 Years Patients with either gender (Male/Female) Patients with recurrent plantar warts

Exclusion Criteria

• Pregnancy/lactation. Pt on topical or systemic therapy in last 6 months. On immunosuppressants. > 5 lesions. Pts with local secondary infections.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
A	Topical Adapalene Gel 0.1%	Treated with Topical adapalene gel 0.1%
B	Topical Liquid Nitrogen application	Treated with liquid nitrogen over affected parts

Primary Outcome Measures

Name	Time	Method
Efficacy of Treatment	06 months	It will be defined through visual inspection by observing the complete clearance of the warts after 8 weeks administration of the treatment in both groups

Trial Locations

Locations (1)

Khyber Teaching Hospital; 🇵🇰 Peshawar, Khyber Pakhtunkhwa, Pakistan