Yellow Fever Human Infection Model With YF-17D
Overview
- Phase
- Not Applicable
- Intervention
- Yellow Fever Vaccine
- Conditions
- Yellow Fever
- Sponsor
- Leiden University Medical Center
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- yellow fever 17D in urine
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
No antiviral treatment exists for yellow fever, only supportive care, and therefore we rely on prevention through vaccination. Although this vaccine is very effective, stockpiles are insufficient in outbreak situations and some people have a contraindication to be vaccinated. For those who are unprotected and at risk of yellow fever infection, treatment could be life saving.
Detailed Description
No antiviral treatment exists for yellow fever, only supportive care, and therefore we rely on prevention through vaccination. Although this vaccine is very effective, stockpiles are insufficient in outbreak situations and some people have a contraindication to be vaccinated. For those who are unprotected and at risk of yellow fever infection, treatment could be life saving.
Investigators
Anna HE Roukens
Principal Investigator
Leiden University Medical Center
Eligibility Criteria
Inclusion Criteria
- •age 18-50 years
Exclusion Criteria
- •contraindication to receive YF-17D (immune deficiency, thymus illness)
- •previous YF vaccination
- •pregnancy
- •chicken egg allergy
- •hypersensitivity to any other substance in the YF-17D vaccine
- •interval of \< 4 weeks of another live attenuated vaccine
Arms & Interventions
intervention arm
yellow fever vaccine arm (all participants receive the standard yellow fever vaccine (Stamaril)
Intervention: Yellow Fever Vaccine
Outcomes
Primary Outcomes
yellow fever 17D in urine
Time Frame: within 30 days of the vaccination
yellow fever 17D in urine at sequential time points after vaccination
Secondary Outcomes
- peak of YF 17D viruria after vaccination(within 30 days of the vaccination)
- YF-17D viremia (in plasma) after vaccination(within 14 days of the vaccination)