The efficacy of Modafinil on working memory in patients with major depressive disorder
Not Applicable
Recruiting
- Conditions
- Major depressive disorder.Major depressive disorder, recurrent, mildF33.0
- Registration Number
- IRCT20091019002611N4
- Lead Sponsor
- Mashhad University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 90
Inclusion Criteria
Confirmed history of major depressive disorder based on the DSM-5 criteria, now in the recovery phase and receiving SSRIs or SNRIs
Beck Depression Inventory score less than 28
18 to 40 years old
The patient has not had more than three episodes
Mean score of 30 for positive affect and 15 for negative affect on Positive and Negative Affect Schedule (PANAS) test
Completing the informed consent form
Exclusion Criteria
Suffering any other major psychiatric illnesses
Thyroid, immunological or neurological problems and other contraindications to Modafinil (such as refractory hypertension or history of cardiac arrhythmia) based on clinical history
Mental retardation
History of head injury or substance abuse
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Working memory capacity, measured by Persian word/non word span test. Timepoint: weeks 0, 2, 4 & 8 of drug administration. Method of measurement: Persian word/non word span test.
- Secondary Outcome Measures
Name Time Method