Study of Cerebral Mechanisms of Visual Recognition With Single-unit Recordings of Intra-cerebral Neurons in Epileptic Patients
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- Number of action potential (Difference of neuronal activity) generated successively by visual presentation of 60 photography of different unknown faces and 60 different objects
Study Overview
Brief Summary
The purpose is to evaluate specific capacities of face detection of individual neurons by comparison with their capacity of object detection in medial temporal lobe and ventral temporal cortex in epileptic patients.
Secondary purpose is to evaluate specific capacities of detection of known faces of individual neurons by comparison with their capacity of detection of unknown faces in medial temporal lobe and ventral temporal cortex in epileptic patients.
Detailed Description
In this interventional study, patients explored with mixed intracerebral electrodes (micro and macro-contacts) will be presented sets of images (objects, unknown faces, famous faces). Spikes and Multi-Unit-Activity will be recorded and analyzed and compared between conditions.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Basic Science
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Patient with temporal or occipito-temporal drug-resistant partial epilepsy, symptomatic, needing surgical treatment
- •Patient having signed informed consent
- •Patient affiliated to social security
- •Patient having undergone preliminary medical examination
Exclusion Criteria
- •Persons under legal protection or incapable to consent
- •Persons deprived of liberty by juridical or administrative decision
- •Patient with severe visual disorders of neurological or ophthalmological origin
- •Patients with infection risk according to doctor or surgeon
- •Women without effective contraception
- •Pregnant or breast-feeding women
Outcomes
Primary Outcomes
Number of action potential (Difference of neuronal activity) generated successively by visual presentation of 60 photography of different unknown faces and 60 different objects
Time Frame: after electrode implantation, up to 12 days
Activity (number of action potential) is recorded for each neuron before and after visualization of each image.
Secondary Outcomes
- Number of action potential (Difference of neuronal activity) generated by visual presentation of 60 photography of a known target face (familiar) and 60 photography of unknown faces (non familiar)(after electrode implantation, up to 12 days)