Time-Restricted Eating and Exercise Training to Enhance Bone Health in Adults With Osteopenia
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 24
- 试验地点
- 1
- 主要终点
- Bone mineral density
研究概览
简要总结
The purpose of this study is to learn whether combining time-restricted eating with supervised resistance exercise can improve bone health in adults with osteopenia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 50 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Men and women aged 50-75 years with body mass index (BMI) >25kg/m2
- •Osteopenia, defined as a T score between -1.0 and -2.5 at the lumbar spine, femoral neck, or total hip
- •Elevated adiposity, defined by waist circumference >102 cm in men or >88 cm in women
- •Stable health history over the past 2 months
- •Stable medication history over the past 2 months, as recommended by the primary provider
- •Willing and able to provide informed consent
排除标准
- •Participation in a formal weight loss program, intentional caloric restriction, fasting >10 hours/day, or ≥10 pounds weight loss within the past 3 months
- •Current participation in structured exercise training, supervised rehabilitation, or >150 minutes/week of moderate intensity physical activity
- •Medical conditions or use of medications affecting bone metabolism
- •Diagnosed diabetes or use of insulin or glucose lowering medications
- •Resting heart rate >120 beats/minute or daytime blood pressure ≥180/100 mmHg
- •Unstable angina, myocardial infarction, or stroke within the past 3 months
- •Continuous supplemental oxygen use for chronic pulmonary disease or heart failure
- •Rheumatoid arthritis, Parkinson's disease, dialysis, active cancer treatment within the past year, or diagnosed cognitive impairment
- •Absolute contraindications to exercise training according to American College of Sports Medicine guidelines
- •Unable to fast for 16 hours
- •Any condition that in the opinion of the investigator would impair ability to participate in the trial
研究组 & 干预措施
Time-restricted eating combined with resistance exercise (TRE+Ex)
Participants in the TRE+Ex group will be asked to fast for a target of 16 hours per day, consuming food ad libitum within an 8-hour eating window beginning between 6:30 and 9:30 AM, 6 days per week for 12 weeks. They will also complete supervised progressive resistance exercise training 3 days per week.
干预措施: Time-restricted eating combined with resistance exercise (TRE+Ex) (Behavioral)
Habitual eating pattern combined with resistance exercise (HE+Ex)
Participants in the HE+Ex group will be instructed to maintain their habitual eating patterns and complete supervised progressive resistance exercise training 3 days per week.
干预措施: Habitual eating pattern combined with resistance exercise (HE+Ex) (Behavioral)
结局指标
主要结局
Bone mineral density
时间窗: Baseline and 12 weeks
measured by dual-energy X-ray absorptiometry
Bone mineral content
时间窗: Baseline and 12 weeks
measured by dual-energy X-ray absorptiometry
次要结局
未报告次要终点
研究者
Yi Lin
Assistant Professor
University of Alabama at Birmingham