Effect of corticosteroids on body cells survival in patients with acute asthma

Not Applicable

Conditions: Health Condition 1: null- acute exacerbation of bronchial asthma with no other associated illness

Registration Number: CTRI/2014/08/004833

Lead Sponsor: lady hardinge medical college new delhi

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Open to Recruitment

Sex: Not specified

Target Recruitment: 60

Inclusion Criteria

All diagnosed patients of bronchial asthma (age group 18-55 years of either sex) presenting with exacerbation, as defined by

-patient breathlessness on slight walking/talking/at rest

-patient able to talk in only words/phrases/incomplete sentences without breathlessness

-respiratory rate >20 per minute

-presence of wheezing on chest auscultation

and undergoing treatment for the same, either on outdoor patient basis or admitted to a medicine unit of Smt. Sucheta Kriplani Hospital, New Delhi will be included in the study.

Exclusion Criteria

The following patients will be excluded from the study-

i.Patient with any other co-existent and active pulmonary or non-pulmonary pathology.

ii.Patient on drug treatment for any other concomitant disease or disorder.

iii.Imminent respiratory arrest as indicated by-

-Drowsy/confused patient.

-Paradoxical thoraco-abdominal movements with respiration.

-Absent wheeze.

-Bradycardia (pulse <60 per minute).

iv.Evidence of active infection on chest X-ray.

v.Patient who received systemic corticosteroid in last 4 weeks.

vi.Patients who are contraindicated for systemic corticosteroids.

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in serum levels of survivin and M 30 apoptosense in acute exacerbation of asthma patients on treatment with systemic corticosteroids.Timepoint: At the initiation of systemic corticosteroids, then 7 days later, and then depending upon improvement in symptoms 21 days thereafter

Secondary Outcome Measures

Name	Time	Method
Correlation between asthma severity score as measured by SOA questionnaire and apoptotic marker level. <br/ ><br>Change in acute quality of life scores in asthma as measured by QOLtech AQLQ questionnaire, after treatment with systemic corticosteroids. <br/ ><br>Timepoint: At the initiation of systemic corticosteroids, then 7 days later, and then depending upon improvement in symptoms 21 days thereafter