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临床试验/NCT01477216
NCT01477216Unknown不适用

The Glycemic and Insulinemic Responses of the Finnish Foods: Measurement and Modification

Finnish Institute for Health and Welfare0 个研究点目标入组 142 人开始时间: 2003年1月1日最近更新:
适应症

试验速览

阶段
不适用
发起方
入组人数
142
主要终点
Free fatty acids

研究概览

简要总结

The aim of this study to investigate methodological aspects that may affect glycemic index (GI) and insulinemic (II) values. In addition, we will measure GI and II values for typical Finnish carbohydrate-rich foods and provide a database of GIs for Finnish foods.

The specific aims of this study are:

  • to compare glycemic responses and GIs analyzed from capillary and venous blood to compare glucose against white bread as the reference food, and to study the effect of number of reference tests on GI values. For each setting of the tested parameters, we determined the glycemic indices of rye bread, oatmeal porridge and instant mashed potato
  • to examine the glycaemic and insulinaemic responses of a mashed potato-based meal when a high fat food (rapeseed oil) or a high protein food (chicken breast) or fat, protein and salad together were added to the meal. Furthermore, we studied how the predicted and measured GI values of the mixed meal differed from each other.
  • to examine the effects of two different coffee portions with glucose and caffeine-containing soft drinks on postprandial glucose and insulin responses. Further objectives were to study how coffee and different accompaniments affect glucose and insulin responses.
  • to measure GI values for typical Finnish foods
  • to study the effects of berries on glycemic and insulinemic responses
  • to examine the effects of overweight and glucose tolerance on the glucose, insulin and lipid responses to an HGI meal and an LGI meal.Furthermore, the second aim was to study the effect of BMI and glucose tolerance on the GI measured.
  • to compare methodological choices in insulin measurement
  • to investigate the effect of alcohol on postprandial glucose and insulin responses, and to determine glycemic and insulinemic indices values for beer and non-alcoholic beer

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Crossover
主要目的
Basic Science
盲法
Single (Participant)

入排标准

年龄范围
20 Years 至 72 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • For Studies 1-9 a total of 12 to 24 volunteers per study with a normal glucose tolerance based upon a 2 h 75g oral glucose tolerance test (OGTT).
  • For Study 7 a total of 24 volunteers with impaired glucose tolerance based on an OGTT.
  • For Studies 1-6 and 8-9 with an age of 20 to 60 and with a BMI of 18 to 30 kg/m
  • For Study 7 an age of 62 to 72 and with a BMI of 20 to 35 kg/m2.

排除标准

  • First-degree family history of diabetes
  • An active gastrointestinal or metabolic disease
  • For Studies 1-6 and 8-9 chronic medication (oral contraceptives were allowed)
  • For Study 7 regular medication that would have affect glucose and lipid metabolism
  • Pregnancy
  • Breastfeeding
  • History of polycystic ovary syndrome
  • History of gestational diabetes

结局指标

主要结局

Free fatty acids

时间窗: 2 to 5 hours

Area under the plasma concentration versus time curve (AUC) of food

Glucose

时间窗: 2 to 5 hours

Area under the plasma concentration versus time curve (AUC) of food

Insulin

时间窗: 2 to 5 hours

Area under the plasma concentration versus time curve (AUC) of food

Triglyserides

时间窗: 2 to 5 hours

Area under the plasma concentration versus time curve (AUC) of food

次要结局

  • Satiety(2 to 5 hours)
  • IGF1(2 to 5 hours)
  • IGF-BP1(2 to 5 hours)

研究者

发起方
Finnish Institute for Health and Welfare
申办方类型
Other Gov
责任方
Sponsor

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