Photodynamic Therapy in Treatment of Verrucae

Not Applicable

• Conditions: Verruca Vulgaris
• Interventions: Other: methylene blue / IPL; Other: saline; Other: IPL

• Registration Number: NCT04620785
• Lead Sponsor: Alexandria University

Brief Summary

To assess the efficacy (clinically and dermoscopically) and safety of photodynamic therapy using intralesional injection of 4% methylene blue solution as a photosensitizer with IPL versus IPL only in treatment of warts.

Detailed Description

This study will be conducted on:

Eighty patients suffering of verruca (male and female) divided randomly into three groups: group A, B\&C :

Group A: 30 patients will undergo photodynamic therapy using intralesional 4%methylene blue solution and IPL.

Group B: 30 patients will undergo IPL only. Group C (control group):20 patients will undergo intralesional saline.

Study Timeline

• Study Start: 2020-01-01
• Study First Submitted: 2020-11-03
• Study First Submitted QC: 2020-11-03
• Study First Posted: 2020-11-09
• Status Verified: 2021-07
• Last Update Submitted: 2021-07-23
• Last Update Posted: 2021-07-26
• Primary Completion: 2022-05-01
• Study Completion: 2022-05-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

1. Age:Above 16 years old.
2. Sex:Both males and female patients.
3. Clinically and dermoscopically documented verruca.
4. No verruca treatment in the last 2 weeks.

Exclusion Criteria

1. History of photosensitivity disorder.
2. Pregnant and lactating females.
3. Diseases with risk of koebnerization e.g. Psoriasis and Lichen planus.
4. Anogenital warts.
5. Warts on head and neck.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
methylene blue/IPL	methylene blue / IPL	will undergo photodynamic therapy using intralesional 4%methylene blue solution ,after a period of 15 minutes the patient will be subjected to IPL session. This will be repeated biweekly until complete clearance of the lesion or a maximum four sessions.
saline	saline	will undergo intralesional saline.
IPL	IPL	will undergo biweekly IPL sessions only until complete clearance of the lesion or a maximum four sessions.

Primary Outcome Measures

Name	Time	Method
disappearance of verruca	10 weeks	clinical and dermoscopic cure

Trial Locations

Locations (1)

Alexandria University Faculty of Medicine; 🇪🇬 Alexandria, Egypt